Use of the National Cancer Data Base to develop clinical trials accrual targets that are appropriate for minority ethnicity patients
dc.contributor.author | Newman, Lisa A. | en_US |
dc.contributor.author | Lee, Cheryl T. | en_US |
dc.contributor.author | Parekh, Lina Patel | en_US |
dc.contributor.author | Stewart, Andrew K. | en_US |
dc.contributor.author | Thomas, Charles R. | en_US |
dc.contributor.author | Beltran, Robert A. | en_US |
dc.contributor.author | Lucci, Anthony | en_US |
dc.contributor.author | Green, Bettye | en_US |
dc.contributor.author | Ota, David | en_US |
dc.contributor.author | Nelson, Heidi | en_US |
dc.date.accessioned | 2007-01-17T15:52:03Z | |
dc.date.available | 2007-01-17T15:52:03Z | |
dc.date.issued | 2006-01-01 | en_US |
dc.identifier.citation | Newman, Lisa A.; Lee, Cheryl T.; Parekh, Lina Patel; Stewart, Andrew K.; Thomas, Charles R.; Beltran, Robert A.; Lucci, Anthony; Green, Bettye; Ota, David; Nelson, Heidi (2006)."Use of the National Cancer Data Base to develop clinical trials accrual targets that are appropriate for minority ethnicity patients." Cancer 106(1): 188-195. <http://hdl.handle.net/2027.42/49271> | en_US |
dc.identifier.issn | 0008-543X | en_US |
dc.identifier.issn | 1097-0142 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/49271 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16333856&dopt=citation | en_US |
dc.description.abstract | BACKGROUND Disparities in cancer outcome among different subsets of the American population related to ethnic background have been well documented. Clinical trials represent the most powerful strategy for improving cancer treatments, but racial and ethnic minority patients are frequently underrepresented among patients accrued to these protocols. Proof of comparable efficacy for a promising cancer therapy in different groups of patients requires diversity in the clinical trial populations so that study results will be generalizable. Appropriate targets for accrual of minority ethnicity patients have not previously been defined. METHODS The National Cancer Database (NCDB) is maintained jointly by the American Cancer Society and the American College of Surgeons. Information submitted by tumor registries throughout the United States represents an estimated 70% of newly diagnosed cancer cases. The authors analyzed NCDB reports on ethnic distribution of patients with breast, prostate, nonsmall cell lung, and colorectal cancer, stratified by stage of disease at diagnosis. RESULTS African Americans with cancer of the breast and prostate had the most notable patterns of disproportionate representation among populations with advanced-stage disease. The authors compiled a table of suggested accrual targets for selected solid-organ cancers based on NCDB stage-specific reports. CONCLUSIONS Clinical trial results will be more meaningful if participating patients reflect the site- and stage-specific populations that are under study. The authors recommended that clinical trial investigators incorporate accrual targets for minority ethnicity populations into the study design. Cancer 2006. © 2005 American Cancer Society. | en_US |
dc.format.extent | 175647 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Use of the National Cancer Data Base to develop clinical trials accrual targets that are appropriate for minority ethnicity patients | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan, Ann Arbor, Michigan ; Fax: (734) 647-9647 ; Breast Care Center, University of Michigan Comprehensive Cancer Center, 1500 E. Medical Center Drive, 3308 Cancer Center, Ann Arbor, MI 48109-0932 | en_US |
dc.contributor.affiliationum | Department of Urology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | American College of Surgeons Commission on Cancer, Chicago, Illinois | en_US |
dc.contributor.affiliationother | American College of Surgeons Commission on Cancer, Chicago, Illinois | en_US |
dc.contributor.affiliationother | Department of Radiation Oncology, Oregon Health & Science University School of Medicine, Portland, Oregon | en_US |
dc.contributor.affiliationother | Latino Med Policy Group, Chicago, Illinois | en_US |
dc.contributor.affiliationother | Department of Surgery, University of Texas M.D. Anderson Cancer Center, Houston, Texas | en_US |
dc.contributor.affiliationother | Latino Med Policy Group, Chicago, Illinois | en_US |
dc.contributor.affiliationother | Department of Surgery, Duke University, Durham, North Carolina | en_US |
dc.contributor.affiliationother | Department of Surgery, Mayo Clinic, Rochester, Minnesota | en_US |
dc.identifier.pmid | 16333856 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/49271/1/21592_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/cncr.21592 | en_US |
dc.identifier.source | Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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