Effectiveness of ceftriaxone plus doxycycline in the treatment of patients hospitalized with community-acquired pneumonia Presented, in part, at the 6th Annual Meeting of the Society of Hospital Medicine, San Diego, CA, April 1, 2003, and at the 26th Annual Meeting of the Society of General Internal Medicine, Vancouver, BC, Canada, May 3, 2003.
dc.contributor.author | Flanders, Scott A. | en_US |
dc.contributor.author | Dudas, Vicky | en_US |
dc.contributor.author | Kerr, Kathleen | en_US |
dc.contributor.author | McCulloch, Charles E. | en_US |
dc.contributor.author | Gonzales, Ralph | en_US |
dc.date.accessioned | 2007-01-17T15:53:59Z | |
dc.date.available | 2007-01-17T15:53:59Z | |
dc.date.issued | 2006-01 | en_US |
dc.identifier.citation | Flanders, Scott A.; Dudas, Vicky; Kerr, Kathleen; McCulloch, Charles E.; Gonzales, Ralph (2006)."Effectiveness of ceftriaxone plus doxycycline in the treatment of patients hospitalized with community-acquired pneumonia Presented, in part, at the 6th Annual Meeting of the Society of Hospital Medicine, San Diego, CA, April 1, 2003, and at the 26th Annual Meeting of the Society of General Internal Medicine, Vancouver, BC, Canada, May 3, 2003. ." Journal of Hospital Medicine 1(1): 7-12. <http://hdl.handle.net/2027.42/49291> | en_US |
dc.identifier.issn | 1553-5592 | en_US |
dc.identifier.issn | 1553-5606 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/49291 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17219465&dopt=citation | en_US |
dc.description.abstract | BACKGROUND: Limited data exist on the effectiveness of ceftriaxone plus doxycycline in the treatment of patients hospitalized with community-acquired pneumonia (CAP). METHODS: We performed a retrospective cohort study of all adults hospitalized for pneumonia between January 1999 and July 2001 at an academic medical center. Outcomes were compared for patients with CAP treated with ceftriaxone plus doxycycline versus other appropriate initial empiric antibiotic therapies. Outcomes were adjusted with the use of a propensity score to account for differences in patient characteristics and illness severity between groups. RESULTS: A total of 216 patients were treated with ceftriaxone plus doxycycline and 125 received other appropriate initial empiric antibiotic therapies. After adjustment, use of ceftriaxone plus doxycycline was associated with reduced inpatient mortality (OR = 0.26, 95% CI: 0.08–0.81) and 30-day mortality (OR = 0.37, 95% CI: 0.17–0.81), but not with length of stay or readmission rates. Analysis of a subset of the sample that excluded patients admitted from nursing homes, patients admitted to the ICU, and patients diagnosed with aspiration also showed reduced inpatient mortality with the use of ceftriaxone plus doxycycline. CONCLUSIONS: The use of ceftriaxone plus doxycycline as an initial empiric therapy for patients hospitalized with CAP appears safe and effective, and its potential superiority should be evaluated prospectively. Journal of Hospital Medicine 2006;1:7–12. © 2006 Society of Hospital Medicine. | en_US |
dc.format.extent | 80973 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Hospital Medicine | en_US |
dc.title | Effectiveness of ceftriaxone plus doxycycline in the treatment of patients hospitalized with community-acquired pneumonia Presented, in part, at the 6th Annual Meeting of the Society of Hospital Medicine, San Diego, CA, April 1, 2003, and at the 26th Annual Meeting of the Society of General Internal Medicine, Vancouver, BC, Canada, May 3, 2003. | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Medicine, University of Michigan, Ann Arbor, Michigan ; Fax: (734) 615-8401 ; University of Michigan, 3119F Taubman Center, Box 0376, 1500 E. Medical Center Drive, Ann Arbor, MI 48109 | en_US |
dc.contributor.affiliationother | Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, San Francisco, California | en_US |
dc.contributor.affiliationother | Department of Medicine, University of California, San Francisco, San Francisco, California | en_US |
dc.contributor.affiliationother | Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California | en_US |
dc.contributor.affiliationother | Department of Medicine, University of California, San Francisco, San Francisco, California ; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California ; Division of General Internal Medicine, University of California, San Francisco, San Francisco, California | en_US |
dc.identifier.pmid | 17219465 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/49291/1/8_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jhm.8 | en_US |
dc.identifier.source | Journal of Hospital Medicine | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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