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Alteration in the Hypothalamic-Pituitary-Ovarian in Depressed Women

dc.contributor.authorYoung, Elizabeth A.en_US
dc.contributor.authorMidgley, A. Reesen_US
dc.contributor.authorCarlson, Nichole E.en_US
dc.contributor.authorBrown, Morton B.en_US
dc.date.accessioned2007-03-16T18:28:33Z
dc.date.available2007-03-16T18:28:33Z
dc.date.issued2000-12en_US
dc.identifier.citationArchives of General Psychiatry 57:1157-62, 2000 <http://hdl.handle.net/2027.42/49488>en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/49488
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11115329&dopt=citationen_US
dc.descriptionfinal versionen_US
dc.description.abstractBackground: Stress and corticotropin-releasing hormone inhibit the reproductive axis.Wehypothesized that reproductive axis hormone secretion, particularly luteinizing hormone secretion, is inhibited in women with depression, similar to what has been observed to be caused by stress in numerous species. Methods: Blood samples were collected every 10 minutes for 12 hours in 25 untreated premenopausal women with depression and 25 nondepressed women who were matched by age and menstrual cycle day. Samples were assayed for luteinizing hormone, follicle-stimulating hormone, estradiol, and progesterone. Results: The mean plasma estradiol level was 30% lower in the follicular phase in women with depression than in their matched controls: 191±136 vs 261±169 pmol/L (52±37 vs 71±46 pg/mL). The half-life of luteinizing hormone was significantly shorter in women with depression than in their matched controls during both the follicular (22% shorter) and luteal (15% shorter) phases. Conclusions: The blood levels of reproductive hormones were mostly normal in women with depression, but the blood level of estradiol was significantly lower. Estradiol is known to affect a number of neurotransmitter systems in the brain.en_US
dc.description.sponsorshipNIMH MH 50030en_US
dc.format.extent1347 bytes
dc.format.extent107495 bytes
dc.format.mimetypetext/plain
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.publisherAMAen_US
dc.subjectOvarian Hormonesen_US
dc.subjectDepressionen_US
dc.titleAlteration in the Hypothalamic-Pituitary-Ovarian in Depressed Womenen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumPsychiatryen_US
dc.contributor.affiliationumMolecular and Behavioral Neurosciences Instituteen_US
dc.contributor.affiliationumReproductive Sciences Programen_US
dc.contributor.affiliationotherReproductive Sciences Programen_US
dc.contributor.affiliationotherBiostatisticsen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid11115329en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/49488/2/YoungHPG.pdfen_US
dc.owningcollnameMolecular and Behavioral Neurosciences Institute


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