Alteration in the Hypothalamic-Pituitary-Ovarian in Depressed Women
dc.contributor.author | Young, Elizabeth A. | en_US |
dc.contributor.author | Midgley, A. Rees | en_US |
dc.contributor.author | Carlson, Nichole E. | en_US |
dc.contributor.author | Brown, Morton B. | en_US |
dc.date.accessioned | 2007-03-16T18:28:33Z | |
dc.date.available | 2007-03-16T18:28:33Z | |
dc.date.issued | 2000-12 | en_US |
dc.identifier.citation | Archives of General Psychiatry 57:1157-62, 2000 <http://hdl.handle.net/2027.42/49488> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/49488 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11115329&dopt=citation | en_US |
dc.description | final version | en_US |
dc.description.abstract | Background: Stress and corticotropin-releasing hormone inhibit the reproductive axis.Wehypothesized that reproductive axis hormone secretion, particularly luteinizing hormone secretion, is inhibited in women with depression, similar to what has been observed to be caused by stress in numerous species. Methods: Blood samples were collected every 10 minutes for 12 hours in 25 untreated premenopausal women with depression and 25 nondepressed women who were matched by age and menstrual cycle day. Samples were assayed for luteinizing hormone, follicle-stimulating hormone, estradiol, and progesterone. Results: The mean plasma estradiol level was 30% lower in the follicular phase in women with depression than in their matched controls: 191±136 vs 261±169 pmol/L (52±37 vs 71±46 pg/mL). The half-life of luteinizing hormone was significantly shorter in women with depression than in their matched controls during both the follicular (22% shorter) and luteal (15% shorter) phases. Conclusions: The blood levels of reproductive hormones were mostly normal in women with depression, but the blood level of estradiol was significantly lower. Estradiol is known to affect a number of neurotransmitter systems in the brain. | en_US |
dc.description.sponsorship | NIMH MH 50030 | en_US |
dc.format.extent | 1347 bytes | |
dc.format.extent | 107495 bytes | |
dc.format.mimetype | text/plain | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_US | en_US |
dc.publisher | AMA | en_US |
dc.subject | Ovarian Hormones | en_US |
dc.subject | Depression | en_US |
dc.title | Alteration in the Hypothalamic-Pituitary-Ovarian in Depressed Women | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Psychiatry | en_US |
dc.contributor.affiliationum | Molecular and Behavioral Neurosciences Institute | en_US |
dc.contributor.affiliationum | Reproductive Sciences Program | en_US |
dc.contributor.affiliationother | Reproductive Sciences Program | en_US |
dc.contributor.affiliationother | Biostatistics | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 11115329 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/49488/2/YoungHPG.pdf | en_US |
dc.owningcollname | Molecular and Behavioral Neurosciences Institute |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.