X-linked bulbospinomuscular atrophy (Kennedy's disease) masquerading as lead neuropathy
dc.contributor.author | Albers, James W. | en_US |
dc.contributor.author | Bromberg, Mark B. | en_US |
dc.date.accessioned | 2007-04-06T18:33:23Z | |
dc.date.available | 2007-04-06T18:33:23Z | |
dc.date.issued | 1994-04 | en_US |
dc.identifier.citation | Albers, James W.; Bromberg, Mark B. (1994)."X-linked bulbospinomuscular atrophy (Kennedy's disease) masquerading as lead neuropathy." Muscle & Nerve 17(4): 419-423. <http://hdl.handle.net/2027.42/50160> | en_US |
dc.identifier.issn | 0148-639X | en_US |
dc.identifier.issn | 1097-4598 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50160 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8170488&dopt=citation | en_US |
dc.description.abstract | A 43-year-old male was referred by a veterinarian who evaluated his dog for a seizure and suspected a toxic lead exposure for both. He refurbished houses, removing old paint, and complained of decreased cognition, fatigue, and muscle cramps. He had a depressed affect, postural tremor, right arm weakness with partial denervation on EMG, and borderline-low sensory nerve action potential (SNAP) amplitudes. A mild anemia and elevated serum and urine lead levels supported a diagnosis of lead neuropathy. Chelation therapy increased urine lead excretion without symptomatic improvement. His brother worked part-time with him and developed similar findings, but also had difficulty chewing, dysphagia, perioral twitching, gynecomastia, and multifocal denervation of extremity and facial muscles. His lead levels were not elevated, but an androgen receptor mutation identified on the X chromosome for both brothers confirmed the diagnosis of X-linked bulbospinomuscular atrophy (Kennedy's disease). © 1994 John Wiley & Sons, Inc. | en_US |
dc.format.extent | 418280 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | X-linked bulbospinomuscular atrophy (Kennedy's disease) masquerading as lead neuropathy | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan ; Department of Neurology, 1914 Taubman Center, University of Michigan Medical Center, Ann Arbor, Ml 48109-0316 | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan | en_US |
dc.identifier.pmid | 8170488 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50160/1/880170409_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/mus.880170409 | en_US |
dc.identifier.source | Muscle & Nerve | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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