Altered serotonin synthesis in the dentatothalamocortical pathway in autistic boys
dc.contributor.author | Chugani, Diane C. | en_US |
dc.contributor.author | Muzik, Otto | en_US |
dc.contributor.author | Rothermel, Robert D. | en_US |
dc.contributor.author | Behen, Michael E. | en_US |
dc.contributor.author | Chakraborty, Pulak K. | en_US |
dc.contributor.author | Mangner, Thomas J. | en_US |
dc.contributor.author | Da Silva, Ednea A. | en_US |
dc.contributor.author | Chugani, Harry T. | en_US |
dc.date.accessioned | 2007-04-06T18:56:18Z | |
dc.date.available | 2007-04-06T18:56:18Z | |
dc.date.issued | 1997-10 | en_US |
dc.identifier.citation | Chugani, Diane C.; Muzik, Otto; Rothermel, Robert; Behen, Michael; Chakraborty, Pulak; Mangner, Thomas; Da Silva, EdnÉ A.; Chugani, Harry T. (1997)."Altered serotonin synthesis in the dentatothalamocortical pathway in autistic boys." Annals of Neurology 42(4): 666-669. <http://hdl.handle.net/2027.42/50366> | en_US |
dc.identifier.issn | 0364-5134 | en_US |
dc.identifier.issn | 1531-8249 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50366 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9382481&dopt=citation | en_US |
dc.description.abstract | Based on reports of increased platelet serotonin in 30 to 50% of autistic subjects, abnormal serotonergic neurotransmission may be important in the pathogenesis of autism. However, serotonin metabolite measurements in cerebrospinal fluid of autistic subjects have failed to demonstrate consistent abnormalities. Using Α-[ 11 C]methyl- L −tryptophan as a tracer for serotonin synthesis with positron emission tomography, we now report unilateral alterations of serotonin synthesis in the dentatothalamocortical pathway in autistic boys. Asymmetries of serotonin synthesis were found in frontal cortex, thalamus, and dentate nucleus of the cerebellum in all 7 boys, but not in the 1 autistic girl studied. Decreased serotonin synthesis was found in the left frontal cortex and thalamus in 5 of the 7 boys and in the right frontal cortex and thalamus in the 2 remaining autistic boys. In all 7 cases, elevated serotonin synthesis in the contralateral dentate nucleus was observed. Statistically significant differences between autistic boys and their nonautistic siblings (n = 5) were obtained when comparing asymmetry indices for frontal cortex, thalamus, and dentate nucleus combined as well as individually for frontal cortex and thalamus. These serotonergic abnormalities in a brain pathway, important for language production and sensory integration, may represent one mechanism underlying the pathophysiology of autism. | en_US |
dc.format.extent | 419216 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology, and Psychiatry | en_US |
dc.title | Altered serotonin synthesis in the dentatothalamocortical pathway in autistic boys | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI ; Department of Radiology, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI | en_US |
dc.contributor.affiliationother | Department of Radiology, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI | en_US |
dc.contributor.affiliationother | Department of Psychiatry, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI | en_US |
dc.contributor.affiliationother | Department of Psychiatry, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI | en_US |
dc.contributor.affiliationother | Department of Radiology, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI | en_US |
dc.contributor.affiliationother | Department of Radiology, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI ; Department of Radiology, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI ; Department of Neurology, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI ; Children's Hospital of Michigan PET Center, 3901 Beaubien Blvd, Detroit, MI 48201 | en_US |
dc.identifier.pmid | 9382481 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50366/1/410420420_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ana.410420420 | en_US |
dc.identifier.source | Annals of Neurology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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