Using fMRI to dissociate sensory encoding from cognitive evaluation of heat pain intensity
dc.contributor.author | Kong, Jian | en_US |
dc.contributor.author | White, Nathan S. | en_US |
dc.contributor.author | Kwong, Kenneth K. | en_US |
dc.contributor.author | Vangel, Mark G. | en_US |
dc.contributor.author | Rosman, Ilana S. | en_US |
dc.contributor.author | Gracely, Richard H. | en_US |
dc.contributor.author | Gollub, Randy L. | en_US |
dc.date.accessioned | 2007-09-18T19:22:19Z | |
dc.date.available | 2007-09-18T19:22:19Z | |
dc.date.issued | 2006-09 | en_US |
dc.identifier.citation | Kong, Jian; White, Nathan S.; Kwong, Kenneth K.; Vangel, Mark G.; Rosman, Ilana S.; Gracely, Richard H.; Gollub, Randy L. (2006). "Using fMRI to dissociate sensory encoding from cognitive evaluation of heat pain intensity." Human Brain Mapping 27(9): 715-721. <http://hdl.handle.net/2027.42/55800> | en_US |
dc.identifier.issn | 1065-9471 | en_US |
dc.identifier.issn | 1097-0193 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/55800 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16342273&dopt=citation | en_US |
dc.description.abstract | Neuroimaging studies of painful stimuli in humans have identified a network of brain regions that is more extensive than identified previously in electrophysiological and anatomical studies of nociceptive pathways. This extensive network has been described as a pain matrix of brain regions that mediate the many interrelated aspects of conscious processing of nociceptive input such as perception, evaluation, affective response, and emotional memory. We used functional magnetic resonance imaging in healthy human subjects to distinguish brain regions required for pain sensory encoding from those required for cognitive evaluation of pain intensity. The results suggest that conscious cognitive evaluation of pain intensity in the absence of any sensory stimulation activates a network that includes bilateral anterior insular cortex/frontal operculum, dorsal lateral prefrontal cortex, bilateral medial prefrontal cortex/anterior cingulate cortex, right superior parietal cortex, inferior parietal lobule, orbital prefrontal cortex, and left occipital cortex. Increased activity common to both encoding and evaluation was observed in bilateral anterior insula/frontal operculum and medial prefrontal cortex/anterior cingulate cortex. We hypothesize that these two regions play a crucial role in bridging the encoding of pain sensation and the cognitive processing of sensory input. Hum Brain Mapp, 2005. © 2005 Wiley-Liss, Inc. | en_US |
dc.format.extent | 219110 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Using fMRI to dissociate sensory encoding from cognitive evaluation of heat pain intensity | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Kinesiology and Sports | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Chronic Pain and Fatigue Research Center, Departments of Medicine-Rheumatology and Neurology, The University of Michigan Health System and VAMC, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Department of Psychiatry, Massachusetts General Hospital, Charlestown, Massachusetts, USA ; 149 13th Street, Room 2661, Charlestown, MA 02129 | en_US |
dc.contributor.affiliationother | MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA | en_US |
dc.contributor.affiliationother | MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA | en_US |
dc.contributor.affiliationother | MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA ; MGH/MIT GCRC Biomedical Imaging Core, Massachusetts General Hospital, Charlestown, Massachusetts, USA | en_US |
dc.contributor.affiliationother | Department of Psychiatry, Massachusetts General Hospital, Charlestown, Massachusetts, USA | en_US |
dc.contributor.affiliationother | Department of Psychiatry, Massachusetts General Hospital, Charlestown, Massachusetts, USA ; MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA ; MGH/MIT GCRC Biomedical Imaging Core, Massachusetts General Hospital, Charlestown, Massachusetts, USA | en_US |
dc.identifier.pmid | 16342273 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/55800/1/20213_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/hbm.20213 | en_US |
dc.identifier.source | Human Brain Mapping | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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