CCR2 expression correlates with prostate cancer progression
dc.contributor.author | Lu, Yi | en_US |
dc.contributor.author | Cai, Zhong | en_US |
dc.contributor.author | Xiao, Guozhi | en_US |
dc.contributor.author | Liu, Yulin | en_US |
dc.contributor.author | Keller, Evan T. | en_US |
dc.contributor.author | Yao, Zhi | en_US |
dc.contributor.author | Zhang, Jian | en_US |
dc.date.accessioned | 2007-09-20T18:28:44Z | |
dc.date.available | 2008-09-08T14:25:13Z | en_US |
dc.date.issued | 2007-06-01 | en_US |
dc.identifier.citation | Lu, Yi; Cai, Zhong; Xiao, Guozhi; Liu, Yulin; Keller, Evan T.; Yao, Zhi; Zhang, Jian (2007)."CCR2 expression correlates with prostate cancer progression." Journal of Cellular Biochemistry 101(3): 676-685. <http://hdl.handle.net/2027.42/56008> | en_US |
dc.identifier.issn | 0730-2312 | en_US |
dc.identifier.issn | 1097-4644 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/56008 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17216598&dopt=citation | en_US |
dc.description.abstract | Although the primary role of chemokines and their receptors is controlling the trafficking of leukocytes during inflammatory responses, they also play pleoitropic roles in cancer development. There is emerging evidence that cancer cells produce chemokines that induce tumor cell proliferation or chemotaxis in various cancer types. We have previously reported that MCP-1 acts as a paracrine and autocrine factor for prostate cancer (PCa) growth and invasion. As the cellular effects of MCP-1 are mediated by CC chemokine receptor 2 (CCR2), we hypothesized that CCR2 may contribute PCa progression. Accordingly, we first determined CCR2 mRNA and protein expression in various cancer cell lines, including PCa and other cancer types. All cells expressed CCR2 mRNA and protein, but in PCa, more aggressive cancer cells such as C4-2B, DU145, and PC3 expressed a higher amount of CCR2 compared with the less aggressive cancer cells such as LNCaP or non-neoplastic PrEC and RWPE-1 cells. Further, we found a positive correlation between CCR2 expression and PCa progression by analyzing an ONCOMINE gene array database. We confirmed that CCR2 mRNA was highly expressed in PCa metastatic tissues compared with the localized PCa or benign prostate tissues by real-time RT-PCR. Finally, CCR2 protein expression was examined by immunohistochemical staining on tissue microarray specimens from 96 PCa patients and 31 benign tissue controls. We found that CCR2 expression correlated with Gleason score and clinical pathologic stages, whereas lower levels of CCR2 were expressed in normal prostate tissues. These results suggest that CCR2 may contribute to PCa development. J. Cell. Biochem. 101: 676–685, 2007. © 2007 Wiley-Liss, Inc. | en_US |
dc.format.extent | 262573 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | CCR2 expression correlates with prostate cancer progression | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Urology, University of Michigan, Ann Arbor, MI 48109 | en_US |
dc.contributor.affiliationother | Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15240 ; Department of Immunology, Tianjin Medical University, Tianjin, China | en_US |
dc.contributor.affiliationother | Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15240 ; Department of Clinical Chemistry, Tianjin Chest Hospital, Tianjin, China | en_US |
dc.contributor.affiliationother | Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15240 | en_US |
dc.contributor.affiliationother | Department of Pathology, Allegheny General Hospital, Pittsburgh, PA 15212 | en_US |
dc.contributor.affiliationother | Department of Immunology, Tianjin Medical University, Tianjin, China | en_US |
dc.contributor.affiliationother | Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15240 ; Department of Medicine, Room 2E110, Pittsburgh VA Healthcare System, Research & Development (151C-U), University Drive, University of Pittsburgh, Pittsburgh, PA 15240. | en_US |
dc.identifier.pmid | 17216598 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/56008/1/21220_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jcb.21220 | en_US |
dc.identifier.source | Journal of Cellular Biochemistry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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