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Zebrafish dou yan mutation causes patterning defects and extensive cell death in the retina

dc.contributor.authorCatalano, Anne E.en_US
dc.contributor.authorRaymond, Pamela A.en_US
dc.contributor.authorGoldman, Daniel J.en_US
dc.contributor.authorWei, Xiangyunen_US
dc.date.accessioned2007-09-20T18:33:02Z
dc.date.available2008-09-08T14:25:14Zen_US
dc.date.issued2007-05en_US
dc.identifier.citationCatalano, Anne E.; Raymond, Pamela A.; Goldman, Daniel; Wei, Xiangyun (2007)."Zebrafish dou yan mutation causes patterning defects and extensive cell death in the retina." Developmental Dynamics 236(5): 1295-1306. <http://hdl.handle.net/2027.42/56024>en_US
dc.identifier.issn1058-8388en_US
dc.identifier.issn1097-0177en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/56024
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17436278&dopt=citationen_US
dc.description.abstractThe size of an organ is largely determined by the number of cells it contains, which in turn is regulated by two opposing processes, cell proliferation and cell death, however, it is generally not clear how cell proliferation and cell death are coordinated during development. Here, we characterize the zebrafish dou yan mi234 mutation that results in a dramatic reduction of retinal size and a disruption of retinal differentiation and lamination. The retinal size reduction is caused by increased retinal cell death in a non–cell-autonomous manner during early development. The phenotypic defect in dou yan mi234 arises coincident with the onset of retinal neurogenesis and differentiation. Interestingly, unlike many other small eye mutations, the mutation does not increase the level of cell death in the brain, suggesting that the brain and retina use different mechanisms to maintain cell survival. Identification and further study of the dou yan gene will enhance our understanding of the molecular mechanisms regulating retinal cellular homeostasis, i.e., the balance between cell proliferation and cell death. Developmental Dynamics 236:1295–1306, 2007. © 2007 Wiley-Liss, Inc.en_US
dc.format.extent929848 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley-Liss, Inc.en_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCell & Developmental Biologyen_US
dc.titleZebrafish dou yan mutation causes patterning defects and extensive cell death in the retinaen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPediatricsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Molecular, Cellular & Developmental Biology, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumMolecular and Behavioral Neuroscience Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationotherDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvaniaen_US
dc.contributor.affiliationotherDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania ; Department of Ophthalmology, University of Pittsburgh School of Medicine, 203 Lothrop Street, Pittsburgh, PA 15213en_US
dc.identifier.pmid17436278en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/56024/1/21148_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/dvdy.21148en_US
dc.identifier.sourceDevelopmental Dynamicsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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