Myxovirus-1 and protein kinase haplotypes and fibrosis in chronic hepatitis C virus Potential conflict of interest: Nothing to report.
dc.contributor.author | Yee, Leland J. | en_US |
dc.contributor.author | Tang, Yong-Ming | en_US |
dc.contributor.author | Kleiner, David E. | en_US |
dc.contributor.author | Wang, Dai | en_US |
dc.contributor.author | Im, Kyung Ah | en_US |
dc.contributor.author | Wahed, Abdus S. | en_US |
dc.contributor.author | Tong, Xiaomei | en_US |
dc.contributor.author | Rhodes, Shannon | en_US |
dc.contributor.author | Su, Xiaowen | en_US |
dc.contributor.author | Whelan, R. Margaret | en_US |
dc.contributor.author | Fontana, Robert John | en_US |
dc.contributor.author | Ghany, Marc G. | en_US |
dc.contributor.author | Borg, Brian | en_US |
dc.contributor.author | Liang, T. Jake | en_US |
dc.contributor.author | Yang, Huiying | en_US |
dc.date.accessioned | 2007-09-20T18:44:09Z | |
dc.date.available | 2008-09-08T14:25:12Z | en_US |
dc.date.issued | 2007-07 | en_US |
dc.identifier.citation | Yee, Leland J.; Tang, Yong-Ming; Kleiner, David E.; Wang, Dai; Im, KyungAh; Wahed, Abdus; Tong, Xiaomei; Rhodes, Shannon; Su, Xiaowen; Whelan, R. Margaret; Fontana, Robert J.; Ghany, Marc G.; Borg, Brian; Liang, T. Jake; Yang, Huiying (2007)."Myxovirus-1 and protein kinase haplotypes and fibrosis in chronic hepatitis C virus Potential conflict of interest: Nothing to report. ." Hepatology 46(1): 74-83. <http://hdl.handle.net/2027.42/56064> | en_US |
dc.identifier.issn | 0270-9139 | en_US |
dc.identifier.issn | 1527-3350 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/56064 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17526009&dopt=citation | en_US |
dc.description.abstract | Candidate genes, including myxovirus resistance-1 (Mx1), protein kinase (PKR), transforming growth factor- Β 1 (TGF-Β), interleukin-10 (IL-10), and interferon-gamma (IFN-Γ), were evaluated for associations with liver fibrosis in 374 treatment-naive patients with genotype-1 chronic HCV infection [194 Caucasian Americans (CAs) and 180 African Americans (AAs)], using a genetic haplotype approach. Among the 18 haplotypes that occurred with a frequency ≥5% in the cohort overall, the Mx1-(-123C)-(+6886A)-(+19820G(379V))-(+38645T) (abbreviated Mx1-CAGT), and PKR-(+110T)-(+7949G)-(+13846A)-(+22937T)-(+40342T) (abbreviated PKR-TGATT) haplotypes were independently associated with less severe hepatic fibrosis (Ishak ≥ 3 versus <3). These associations persisted after adjustment for potential confounders such as alcohol use, sex, age (which is strongly correlated with the estimated duration of HCV infection [Spearman's correlation coefficient ( r s ) = 0.6)], and race (for Mx1-CAGT : OR = 0.33; 95% CI: 0.16-0.68; P = 0.0027; and for PKR-TGATT : OR = 0.56; 95% CI: 0.32-0.98; P = 0.0405). Population structure was evaluated using the structured association method using data from 161 ancestry-informative markers and did not affect our findings. We used an independent cohort of 34 AA and 160 CA in an attempt to validate our findings, although notable differences were found in the characteristics of the two patient groups. Although we observed a similar protective trend for the Mx1-CAGT haplotype in the validation set, the association was not statistically significant. Conclusion: In addition to other factors, polymorphisms in cytokine genes may play a role in the progression of HCV-related fibrosis; however, further studies are needed. (H EPATOLOGY 2007.) | en_US |
dc.format.extent | 163055 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Hepatology | en_US |
dc.title | Myxovirus-1 and protein kinase haplotypes and fibrosis in chronic hepatitis C virus Potential conflict of interest: Nothing to report. | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationother | Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA ; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, PA ; fax: 412-624-7397 ; A511 Crabtree Hall, 130 DeSoto Street, Pittsburgh, PA 15232 | en_US |
dc.contributor.affiliationother | Division of Medical Genetics, Department of Pediatrics, Cedars Sinai Medical Center, Los Angeles, CA | en_US |
dc.contributor.affiliationother | National Cancer Institute, National Institutes of Health, Bethesda, MD | en_US |
dc.contributor.affiliationother | Division of Medical Genetics, Department of Pediatrics, Cedars Sinai Medical Center, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA | en_US |
dc.contributor.affiliationother | Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA | en_US |
dc.contributor.affiliationother | Division of Medical Genetics, Department of Pediatrics, Cedars Sinai Medical Center, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Division of Medical Genetics, Department of Pediatrics, Cedars Sinai Medical Center, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Division of Medical Genetics, Department of Pediatrics, Cedars Sinai Medical Center, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA | en_US |
dc.contributor.affiliationother | Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD | en_US |
dc.contributor.affiliationother | Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD | en_US |
dc.contributor.affiliationother | Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD | en_US |
dc.contributor.affiliationother | Division of Medical Genetics, Department of Pediatrics, Cedars Sinai Medical Center, Los Angeles, CA | en_US |
dc.identifier.pmid | 17526009 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/56064/1/21636_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/hep.21636 | en_US |
dc.identifier.source | Hepatology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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