Brain diffusivity in patients with neuropsychiatric systemic lupus erythematosus with new acute neurological symptoms
dc.contributor.author | Welsh, Robert C. | en_US |
dc.contributor.author | Rahbar, Habib | en_US |
dc.contributor.author | Foerster, Bradley R. | en_US |
dc.contributor.author | Thurnher, Majda | en_US |
dc.contributor.author | Sundgren, Pia C. | en_US |
dc.date.accessioned | 2007-09-20T19:08:18Z | |
dc.date.available | 2008-09-08T14:25:14Z | en_US |
dc.date.issued | 2007-09 | en_US |
dc.identifier.citation | Welsh, Robert C.; Rahbar, Habib; Foerster, Bradley; Thurnher, Majda; Sundgren, Pia C. (2007)."Brain diffusivity in patients with neuropsychiatric systemic lupus erythematosus with new acute neurological symptoms." Journal of Magnetic Resonance Imaging 26(3): 541-551. <http://hdl.handle.net/2027.42/56148> | en_US |
dc.identifier.issn | 1053-1807 | en_US |
dc.identifier.issn | 1522-2586 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/56148 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17729344&dopt=citation | en_US |
dc.description.abstract | Purpose To investigate the source of significant difference in apparent diffusion coefficient (ADC) between patients with acute symptoms of neuropsychiatric (NP) systematic lupus erythematosus (SLE) (NPSLE) and normal controls. Materials and Methods Diffusion-weighted echo-planar imaging was performed on 1.5-T scanners in 17 female and four male NPSLE patients with acute neurological symptoms (23–76 years, mean = 42.7 years), and in 21 aged-matched healthy controls (16 female, five male, 26–63 years, mean = 41.1 years). ADC histograms were calculated for whole brain, gray matter tissue, and white matter tissue. Results Of the 17 NPSLE patients, 13 (72%) had abnormal findings on MR imaging. The NPSLE patients had a mean ADC value of (1105.1 ± 23.6) × 10 —6 mm 2 /second and the control had a mean ADC value of (1012.5 ± 9.4) × 10 −6 mm 2 /second ( P ≤ 0.0012). Significant differences were also found in white matter ( P ≤ 0.0020) and gray matter ( P ≤ 0.0022). Conclusion ADC histogram analysis demonstrated increased general diffusivity in the brain in NPSLE patients with acute symptoms compared with healthy normal controls. This finding suggests that in the brain parenchyma of NPSLE patients a loss of tissue integrity occurs facilitating motility of free-water protons. J. Magn. Reson. Imaging 2007;26:541–551. © 2007 Wiley-Liss, Inc. | en_US |
dc.format.extent | 513237 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Imaging | en_US |
dc.title | Brain diffusivity in patients with neuropsychiatric systemic lupus erythematosus with new acute neurological symptoms | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationother | Department of Radiology, University Hospital of Michigan, Ann Arbor, Michigan, USA ; Department of Radiology, Basic Radiological Sciences Division, Kresge III, Room 3315, 200 Zina Pitcher Place, Ann Arbor, MI 48109-0553 | en_US |
dc.contributor.affiliationother | Department of Radiology, University Hospital of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Department of Radiology, University Hospital of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Department of Radiology, Vienna University Hospital, Vienna, Austria | en_US |
dc.contributor.affiliationother | Department of Radiology, University Hospital of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.identifier.pmid | 17729344 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/56148/1/21036_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jmri.21036 | en_US |
dc.identifier.source | Journal of Magnetic Resonance Imaging | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.