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| Title: | Muscimol inactivation of the dorsal hippocampus impairs contextual retrieval of fear memory |
| Authors: | Holt, William
Maren, Stephen |
| Issue Date: | 15-Oct-1999 |
| Citation: | Journal of Neuroscience, 19(20):9054-62. <http://hdl.handle.net/2027.42/56237> |
| Abstract: | Some models of hippocampal function have suggested a role of the hippocampus in contextual memory retrieval. We have examined this hypothesis by assessing the impact of reversible inactivation of the dorsal hippocampus (DH) on the context-specific expression of latent inhibition, a decrement in conditional responding produced by preexposure to a to-be-conditional stimulus. In Experiment 1, rats received tone preexposure either in the context that would later be used for extinction testing (context A) or in a different context (context C); a third group of rats did not receive tone preexposure. All rats then received fear conditioning, which consisted of tone-footshock pairings, in a third distinct context (context B). The following day conditional fear to the tone was assessed in one of the preexposure contexts (context A) by measuring freezing during a tone extinction test. Rats preexposed and tested in the same context exhibited less freezing to the tone than either rats preexposed and tested in different contexts or non-preexposed rats. These results indicate that the expression of latent inhibition is context specific. In Experiment 2, DH inactivation eliminated the context-specific expression of latent inhibition. Compared with saline-infused rats, rats infused with muscimol into the DH exhibited low levels of tone freezing independent of whether they had received tone preexposure in the test context or in a different context. Experiment 3 revealed normal contextual discrimination in rats after DH inactivation. These results suggest the DH is required for contextual memory retrieval in a latent inhibition paradigm. |
| URI: | http://hdl.handle.net/2027.42/56237 |
| Appears in Collections: | Psychology, Department of
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| holtJN99.pdf | | 284Kb | Adobe PDF | View/Open |
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