Effect of body mass index on the survival benefit of liver transplantation This study was approved by HRSA's SRTR project officer. HRSA has determined that this study satisfies the criteria for the IRB exemption described in the “Public Benefit and Service Program” provisions of 45 CFR 46.101(b)(5) and HRSA Circular 03.
dc.contributor.author | Pelletier, Shawn J. | en_US |
dc.contributor.author | Schaubel, Douglas E. | en_US |
dc.contributor.author | Wei, Guanghui | en_US |
dc.contributor.author | Englesbe, Michael J. | en_US |
dc.contributor.author | Punch, Jeffrey D. | en_US |
dc.contributor.author | Wolfe, Robert A. | en_US |
dc.contributor.author | Port, Friedrich K. | en_US |
dc.contributor.author | Merion, Robert M. | en_US |
dc.date.accessioned | 2008-01-04T20:11:39Z | |
dc.date.available | 2009-01-07T20:01:15Z | en_US |
dc.date.issued | 2007-12 | en_US |
dc.identifier.citation | Pelletier, Shawn J.; Schaubel, Douglas E.; Wei, Guanghui; Englesbe, Michael J.; Punch, Jeffrey D.; Wolfe, Robert A.; Port, Friedrich K.; Merion, Robert M. (2007). "Effect of body mass index on the survival benefit of liver transplantation This study was approved by HRSA's SRTR project officer. HRSA has determined that this study satisfies the criteria for the IRB exemption described in the “Public Benefit and Service Program” provisions of 45 CFR 46.101(b)(5) and HRSA Circular 03. ." Liver Transplantation 13(12): 1678-1683. <http://hdl.handle.net/2027.42/57537> | en_US |
dc.identifier.issn | 1527-6465 | en_US |
dc.identifier.issn | 1527-6473 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/57537 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18044787&dopt=citation | en_US |
dc.description.abstract | Obese patients are at higher risk for morbidity and mortality after liver transplantation (LT) than nonobese recipients. However, there are no reports assessing the survival benefit of LT according to recipient body mass index (BMI). A retrospective cohort of liver transplant candidates who were initially wait-listed between September 2001 and December 2004 was identified in the Scientific Registry of Transplant Recipients database. Adjusted Cox regression models were fitted to assess the association between BMI and liver transplant survival benefit (posttransplantation vs. waiting list mortality). During the study period, 25,647 patients were placed on the waiting list. Of these, 4,488 (17%) underwent LT by December 31, 2004. At wait-listing and transplantation, similar proportions were morbidly obese (BMI ≥ 40; 3.8% vs. 3.4%, respectively) and underweight (BMI < 20; 4.5% vs. 4.0%, respectively). Underweight patients experienced a significantly higher covariate-adjusted risk of death on the waiting list (hazard ratio [HR] = 1.61; P < 0.0001) compared to normal weight candidates (BMI 20 to <25), but underweight recipients had a similar risk of posttransplantation death (HR = 1.28; P = 0.15) compared to recipients of normal weight. In conclusion, compared to patients on the waiting list with a similar BMI, all subgroups of liver transplant recipients demonstrated a significant ( P < 0.0001) survival benefit, including morbidly obese and underweight recipients. Our results suggest that high or low recipient BMI should not be a contraindication for LT. Liver Transpl, 2007. © 2007 AASLD. | en_US |
dc.format.extent | 179835 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Surgery | en_US |
dc.title | Effect of body mass index on the survival benefit of liver transplantation This study was approved by HRSA's SRTR project officer. HRSA has determined that this study satisfies the criteria for the IRB exemption described in the “Public Benefit and Service Program” provisions of 45 CFR 46.101(b)(5) and HRSA Circular 03. | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Transplantation, Department of Surgery, University of Michigan, Ann Arbor, MI ; Telephone: 734-936-8363; FAX: 734-763-3187 ; University of Michigan Health System, 2926 Taubman Center, 1500 E. Medical Center Dr., Ann Arbor, MI 48109-0331 | en_US |
dc.contributor.affiliationum | Department of Biostatistics, University of Michigan, Ann Arbor, MI ; Scientific Registry of Transplant Recipients, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Biostatistics, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Division of Transplantation, Department of Surgery, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Division of Transplantation, Department of Surgery, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Division of Transplantation, Department of Surgery, University of Michigan, Ann Arbor, MI ; Scientific Registry of Transplant Recipients, Ann Arbor, MI | en_US |
dc.contributor.affiliationother | Scientific Registry of Transplant Recipients, Ann Arbor, MI ; Arbor Research Collaborative for Health, Ann Arbor, MI | en_US |
dc.contributor.affiliationother | Scientific Registry of Transplant Recipients, Ann Arbor, MI ; Arbor Research Collaborative for Health, Ann Arbor, MI | en_US |
dc.identifier.pmid | 18044787 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/57537/1/21183_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/lt.21183 | en_US |
dc.identifier.source | Liver Transplantation | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.