Relationship of serum fibrosis markers with liver fibrosis stage and collagen content in patients with advanced chronic hepatitis C
dc.contributor.author | Fontana, Robert John | en_US |
dc.contributor.author | Goodman, Zachary D. | en_US |
dc.contributor.author | Dienstag, Jules L. | en_US |
dc.contributor.author | Bonkovsky, Herbert L. | en_US |
dc.contributor.author | Naishadham, Deepa | en_US |
dc.contributor.author | Sterling, Richard K. | en_US |
dc.contributor.author | Su, Grace L. | en_US |
dc.contributor.author | Ghosh, Mita | en_US |
dc.contributor.author | Wright, Elizabeth C. | en_US |
dc.date.accessioned | 2008-03-06T19:10:08Z | |
dc.date.available | 2009-03-04T14:20:46Z | en_US |
dc.date.issued | 2008-03 | en_US |
dc.identifier.citation | Fontana, Robert J.; Goodman, Zachary D.; Dienstag, Jules L.; Bonkovsky, Herbert L.; Naishadham, Deepa; Sterling, Richard K.; Su, Grace L.; Ghosh, Mita; Wright, Elizabeth C. (2008). "Relationship of serum fibrosis markers with liver fibrosis stage and collagen content in patients with advanced chronic hepatitis C Potential conflict of interest: Financial relationships of the authors with Hoffmann-La Roche Inc., are as follows: R.J. Fontana is on the speaker's bureau; R.K. Sterling is a consultant and on the speaker's bureau; Authors with no financial relationships related to this project are: Z.D. Goodman, J.L. Dienstag, D. Naishadham, Grace Su, Mita Ghosh, H.L. Bonkovsky, and E.C. Wright. ." Hepatology 47(3): 789-798. <http://hdl.handle.net/2027.42/58027> | en_US |
dc.identifier.issn | 0270-9139 | en_US |
dc.identifier.issn | 1527-3350 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/58027 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18175357&dopt=citation | |
dc.description.abstract | This study determined the utility of a panel of serum fibrosis markers along with routine laboratory tests in estimating the likelihood of histological cirrhosis in a cohort of prior nonresponders with chronic hepatitis C. The relationship between serum markers and quantitative hepatic collagen content was also determined. Liver biopsy samples from 513 subjects enrolled in the HALT-C trial were assigned Ishak fibrosis scores. The collagen content of 386 sirius-red stained, nonfragmented biopsy samples was quantified using computerized morphometry. Serum tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), amino-terminal peptide of type III procollagen (PIIINP), hyaluronic acid (HA), and YKL-40 levels were determined using commercially available assays.Sixty-two percent of patients had noncirrhotic fibrosis (Ishak stage 2-4) whereas 38% had cirrhosis (Ishak stage 5,6). Multivariate analysis identified a 3-variable model (HA, TIMP-1, and platelet count) that had an area under the receiver operating curve (AUROC) of 0.81 for estimating the presence of cirrhosis. This model was significantly better than that derived from the cirrhosis discriminant score (AUROC 0.70), the AST-to-platelet ratio (AUROC 0.73), and a prior model developed in HALT-C patients (AUROC 0.79). Multivariate analysis demonstrated that the serum fibrosis markers correlated substantially better with Ishak fibrosis scores than with the log hepatic collagen content (AUROC 0.84 versus 0.72). Conclusion: A 3-variable model consisting of serum HA, TIMP-1, and platelet count was better than other published models in identifying cirrhosis in HALT-C Trial subjects. The stronger correlation of the serum markers with Ishak scores suggests that serum fibrosis markers reflect the pattern of fibrosis more closely than the quantity of hepatic collagen. (H EPATOLOGY 2008.) | en_US |
dc.format.extent | 263286 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Hepatology | en_US |
dc.title | Relationship of serum fibrosis markers with liver fibrosis stage and collagen content in patients with advanced chronic hepatitis C | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI ; fax: 734-936-7392 ; Department of Internal Medicine, University of Michigan Medical School, 3912 Taubman Center, Ann Arbor, MI 48109-0362 | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI | en_US |
dc.contributor.affiliationother | Armed Forces Institute of Pathology, Washington, DC | en_US |
dc.contributor.affiliationother | Gastrointestinal Unit, Medical Services, Massachusetts General Hospital, and the Department of Medicine, Harvard Medical School, Boston, MA | en_US |
dc.contributor.affiliationother | Departments of Medicine and Molecular and Structural Biology and The Liver-Biliary-Pancreatic Center, University of Connecticut Health Center, Farmington, CT | en_US |
dc.contributor.affiliationother | New England Research Institutes, Watertown, MA | en_US |
dc.contributor.affiliationother | Hepatology Section, Virginia Commonwealth University Health System, Richmond, VA | en_US |
dc.contributor.affiliationother | Ann Arbor Veteran's Administration Health Center, Ann Arbor, MI | en_US |
dc.contributor.affiliationother | Office of the Director, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD | en_US |
dc.identifier.pmid | 18175357 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/58027/1/22099_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/hep.22099 | en_US |
dc.identifier.source | Hepatology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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