Successful treatment of refractory immune hemolysis following unrelated cord blood transplant with Campath-1H
dc.contributor.author | Chao, Mwe Mwe | en_US |
dc.contributor.author | Levine, John E. | en_US |
dc.contributor.author | Ferrara, James L. M. | en_US |
dc.contributor.author | Cooling, Laura | en_US |
dc.contributor.author | Cooke, Kenneth R. | en_US |
dc.contributor.author | Hutchinson, Raymond J. | en_US |
dc.contributor.author | Yanik, Gregory A. | en_US |
dc.date.accessioned | 2008-03-06T19:12:22Z | |
dc.date.available | 2009-04-09T15:01:13Z | en_US |
dc.date.issued | 2008-04 | en_US |
dc.identifier.citation | Chao, Mwe Mwe; Levine, John E.; Ferrara, James L.; Cooling, Laura; Cooke, Kenneth R.; Hutchinson, Raymond J.; Yanik, Gregory A. (2008). "Successful treatment of refractory immune hemolysis following unrelated cord blood transplant with Campath-1H." Pediatric Blood & Cancer 50(4): 917-919. <http://hdl.handle.net/2027.42/58036> | en_US |
dc.identifier.issn | 1545-5009 | en_US |
dc.identifier.issn | 1545-5017 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/58036 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17417790&dopt=citation | |
dc.description.abstract | Immune-mediated hemolytic anemia is a well-recognized complication of hematopoietic stem cell transplantation. We report on a 6-year-old boy with X-linked adrenoleukodystrophy who developed severe delayed alloimmune hemolytic anemia associated with immune-mediated neutropenia and thrombocytopenia following major ABO incompatible unrelated cord blood transplantation. The patient's cytopenias were refractory to treatment with corticosteroids, cyclosporine, intravenous immune globulin, rituximab, and pentostatin. After one course of Campath-1H his hematologic parameters normalized, suggesting that the compound may be an effective therapy for complex immunohematologic disorders complicating hematopoietic stem cell transplantation. The case also emphasizes the importance of T-cells in transplant associated immune cytopenias. Pediatr Blood Cancer 2008;50:917–919. © 2007 Wiley-Liss, Inc. | en_US |
dc.format.extent | 287845 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Successful treatment of refractory immune hemolysis following unrelated cord blood transplant with Campath-1H | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pediatrics, Division of Pediatric Hematology-Oncology and Blood and Marrow Transplantation, University of Michigan Health System, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pediatrics, Division of Pediatric Hematology-Oncology and Blood and Marrow Transplantation, University of Michigan Health System, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pediatrics, Division of Pediatric Hematology-Oncology and Blood and Marrow Transplantation, University of Michigan Health System, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Laboratory Medicine and Pathology, University of Michigan Health System, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pediatrics, Division of Pediatric Hematology-Oncology and Blood and Marrow Transplantation, University of Michigan Health System, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pediatrics, Division of Pediatric Hematology-Oncology and Blood and Marrow Transplantation, University of Michigan Health System, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pediatrics, Division of Pediatric Hematology-Oncology and Blood and Marrow Transplantation, University of Michigan Health System, Ann Arbor, Michigan ; University of Michigan Health System, 1500 East Medical Centre, 5303 CCGC, Ann Arbor, MI 48109-0914. | en_US |
dc.identifier.pmid | 17417790 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/58036/1/21187_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/pbc.21187 | en_US |
dc.identifier.source | Pediatric Blood & Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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