Performance evaluation of a very high resolution small animal PET imager using silicon scatter detectors
dc.contributor.author | Park, Sang-June | en_US |
dc.contributor.author | Rogers, W. Leslie | en_US |
dc.contributor.author | Huh, Sam | en_US |
dc.contributor.author | Kagan, Harris | en_US |
dc.contributor.author | Honscheid, Klaus | en_US |
dc.contributor.author | Burdette, Don | en_US |
dc.contributor.author | Chesi, Enrico | en_US |
dc.contributor.author | Lacasta, Carlos | en_US |
dc.contributor.author | Llosa, Gabriela | en_US |
dc.contributor.author | Mikuz, Marko | en_US |
dc.contributor.author | Studen, Andrej | en_US |
dc.contributor.author | Weilhammer, Peter | en_US |
dc.contributor.author | Clinthorne, Neal H. | en_US |
dc.date.accessioned | 2008-04-02T14:32:31Z | |
dc.date.available | 2008-04-02T14:32:31Z | |
dc.date.issued | 2007-05-21 | en_US |
dc.identifier.citation | Park, Sang-June; Rogers, W Leslie; Huh, Sam; Kagan, Harris; Honscheid, Klaus; Burdette, Don; Chesi, Enrico; Lacasta, Carlos; Llosa, Gabriela; Mikuz, Marko; Studen, Andrej; Weilhammer, Peter; Clinthorne, Neal H (2007). "Performance evaluation of a very high resolution small animal PET imager using silicon scatter detectors." Physics in Medicine and Biology. 52(10): 2807-2826. <http://hdl.handle.net/2027.42/58094> | en_US |
dc.identifier.issn | 0031-9155 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/58094 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17473353&dopt=citation | en_US |
dc.description.abstract | A very high resolution positron emission tomography (PET) scanner for small animal imaging based on the idea of inserting a ring of high-granularity solid-state detectors into a conventional PET scanner is under investigation. A particularly interesting configuration of this concept, which takes the form of a degenerate Compton camera, is shown capable of providing sub-millimeter resolution with good sensitivity. We present a Compton PET system and estimate its performance using a proof-of-concept prototype. A prototype single-slice imaging instrument was constructed with two silicon detectors 1 mm thick, each having 512 1.4 mm × 1.4 mm pads arranged in a 32 × 16 array. The silicon detectors were located edgewise on opposite sides and flanked by two non-position sensitive BGO detectors. The scanner performance was measured for its sensitivity, energy, timing, spatial resolution and resolution uniformity. Using the experimental scanner, energy resolution for the silicon detectors is 1%. However, system energy resolution is dominated by the 23% FWHM BGO resolution. Timing resolution for silicon is 82.1 ns FWHM due to time-walk in trigger devices. Using the scattered photons, time resolution between the BGO detectors is 19.4 ns FWHM. Image resolution of 980 µm FWHM at the center of the field-of-view (FOV) is obtained from a 1D profile of a 0.254 mm diameter 18F line source image reconstructed using the conventional 2D filtered back-projection (FBP). The 0.4 mm gap between two line sources is resolved in the image reconstructed with both FBP and the maximum likelihood expectation maximization (ML-EM) algorithm. The experimental instrument demonstrates sub-millimeter resolution. A prototype having sensitivity high enough for initial small animal images can be used for in vivo studies of small animal models of metabolism, molecular mechanism and the development of new radiotracers. | en_US |
dc.format.extent | 3118 bytes | |
dc.format.extent | 1803091 bytes | |
dc.format.mimetype | text/plain | |
dc.format.mimetype | application/pdf | |
dc.publisher | IOP Publishing Ltd | en_US |
dc.title | Performance evaluation of a very high resolution small animal PET imager using silicon scatter detectors | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Physics | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Department of Physics, Ohio State University, Columbus, OH, USA | en_US |
dc.contributor.affiliationother | Department of Physics, Ohio State University, Columbus, OH, USA | en_US |
dc.contributor.affiliationother | Department of Physics, Ohio State University, Columbus, OH, USA | en_US |
dc.contributor.affiliationother | CERN, Geneva, Switzerland | en_US |
dc.contributor.affiliationother | IFIC/University of Valencia, Valencia, Spain | en_US |
dc.contributor.affiliationother | IFIC/University of Valencia, Valencia, Spain | en_US |
dc.contributor.affiliationother | Department of Experimental Particle Physics, Institute Jozef Stefan/University of Ljubljana, Ljubljana, Slovenia | en_US |
dc.contributor.affiliationother | Department of Experimental Particle Physics, Institute Jozef Stefan/University of Ljubljana, Ljubljana, Slovenia | en_US |
dc.contributor.affiliationother | CERN, Geneva, Switzerland; Department of Physics, University of Perugia, Perugia, Italy | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 17473353 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/58094/2/pmb7_10_012.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1088/0031-9155/52/10/012 | en_US |
dc.identifier.source | Physics in Medicine and Biology. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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