Notch signaling is necessary for GATA3 function in the initiation of T cell development
dc.contributor.author | Negishi, Naoko | en_US |
dc.contributor.author | Tsuchiya, Izumi | en_US |
dc.contributor.author | Abe, Natsumi | en_US |
dc.contributor.author | Hirano, Ken-ichi | en_US |
dc.contributor.author | Suzuki, Daisuke | en_US |
dc.contributor.author | Yamamoto, Masayuki | en_US |
dc.contributor.author | Engel, James Douglas | en_US |
dc.contributor.author | Habu, Sonoko | en_US |
dc.date.accessioned | 2008-05-12T13:33:33Z | |
dc.date.available | 2009-04-09T15:01:14Z | en_US |
dc.date.issued | 2008-04 | en_US |
dc.identifier.citation | Negishi, Naoko; Tsuchiya, Izumi; Abe, Natsumi; Hirano, Ken-ichi; Suzuki, Daisuke; Yamamoto, Masayuki; Engel, James D.; Habu, Sonoko (2008). "Notch signaling is necessary for GATA3 function in the initiation of T cell development." European Journal of Immunology 38(4): 977-985. <http://hdl.handle.net/2027.42/58545> | en_US |
dc.identifier.issn | 0014-2980 | en_US |
dc.identifier.issn | 1521-4141 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/58545 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18383037&dopt=citation | |
dc.description.abstract | GATA3 and Notch1 are essential for T cell development at the earliest stage, but their mutual roles in this process remain to be clarified. In this study, we demonstrated that impairment of T lymphopoiesis in hematopoietic progenitor cells (HPC) of GATA3-deficient fetal liver (FL) on day 11.5 of gestation (E11.5) was rescued only by introduction of both GATA3 and the intracellular region of Notch1 but not by either alone. However, the introduction of GATA3 only was sufficient for T cell induction in GATA3-deficient FL cells at the advanced stage, where Notch signaling is well detectable. This indicates that Notch signaling is necessary for GATA3 to function for T cell fate specification but is not sufficient without GATA3. On the other hand, Notch signaling is sufficient for blockage of B cell development without GATA3, suggesting that T cell fate specification at the branching point does not result simply from the developmental arrest of B cell lineage by Notch signaling. | en_US |
dc.format.extent | 527694 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | WILEY-VCH Verlag | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Microbiology and Immunology | en_US |
dc.title | Notch signaling is necessary for GATA3 function in the initiation of T cell development | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Department of Immunology, and Research Center for Embryogenesis and Organogenesis, Tokai University School of Medicine, Isehara, Japan | en_US |
dc.contributor.affiliationother | Department of Surgery, Tokai University School of Medicine, Isehara, Japan | en_US |
dc.contributor.affiliationother | Department of Immunology, and Research Center for Embryogenesis and Organogenesis, Tokai University School of Medicine, Isehara, Japan | en_US |
dc.contributor.affiliationother | Department of Immunology, and Research Center for Embryogenesis and Organogenesis, Tokai University School of Medicine, Isehara, Japan | en_US |
dc.contributor.affiliationother | Department of Immunology, and Research Center for Embryogenesis and Organogenesis, Tokai University School of Medicine, Isehara, Japan | en_US |
dc.contributor.affiliationother | Center for Tsukuba Advanced Research Alliance and Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan | en_US |
dc.contributor.affiliationother | Department of Immunology, and Research Center for Embryogenesis and Organogenesis, Tokai University School of Medicine, Isehara, Japan | en_US |
dc.identifier.pmid | 18383037 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/58545/1/977_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/eji.200737688 | en_US |
dc.identifier.source | European Journal of Immunology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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