Transient 23–30 Hz oscillations in mouse hippocampus during exploration of novel environments
dc.contributor.author | Berke, Joshua D. | en_US |
dc.contributor.author | Hetrick, Vaughn | en_US |
dc.contributor.author | Breck, Jason | en_US |
dc.contributor.author | Greene, Robert W. | en_US |
dc.date.accessioned | 2008-05-12T13:40:12Z | |
dc.date.available | 2009-05-04T19:09:21Z | en_US |
dc.date.issued | 2008-05 | en_US |
dc.identifier.citation | Berke, Joshua D.; Hetrick, Vaughn; Breck, Jason; Greene, Robert W. (2008). "Transient 23–30 Hz oscillations in mouse hippocampus during exploration of novel environments." Hippocampus 18(5): 519-529. <http://hdl.handle.net/2027.42/58576> | en_US |
dc.identifier.issn | 1050-9631 | en_US |
dc.identifier.issn | 1098-1063 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/58576 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18398852&dopt=citation | |
dc.description.abstract | The hippocampus is a key brain structure for the encoding of new experiences and environments. Hippocampal activity shows distinct oscillatory patterns, but the relationships between oscillations and memory are not well understood. Here we describe bursts of hippocampal ∼23–30 Hz (beta2) oscillations in mice exploring novel, but not familiar, environments. In marked contrast to the relatively invariant ∼8 Hz theta rhythm, beta2 power was weak during the very first lap of the novel environment, increased sharply as the mice reencountered their start point, then persisted for only a few minutes. Novelty-evoked oscillations reflected precise synchronization of individual neurons, and participating pyramidal cells showed a selective enhancement of spatial specificity. Through focal viral manipulations, we found that novelty-evoked oscillations required functional NMDA receptors in CA3, a subregion critical for fast oscillations in vitro. These findings suggest that beta2 oscillations indicate a hippocampal dynamic state that facilitates the formation of unique contextual representations. © 2008 Wiley-Liss, Inc. | en_US |
dc.format.extent | 1603491 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Transient 23–30 Hz oscillations in mouse hippocampus during exploration of novel environments | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychology, University of Michigan, Ann Arbor, Michigan ; Program in Neuroscience, University of Michigan, Ann Arbor, Michigan ; Department of Psychology, University of Michigan, Ann Arbor, MI 48104, USA | en_US |
dc.contributor.affiliationum | Department of Psychology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Psychology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Department of Psychiatry, University of Texas Southwestern, Dallas, Texas ; Department of Psychiatry, Dallas VAMC, Dallas, Texas | en_US |
dc.identifier.pmid | 18398852 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/58576/1/20435_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/hipo.20435 | en_US |
dc.identifier.source | Hippocampus | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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