Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta
dc.contributor.author | Tian, Geng | en_US |
dc.contributor.author | Singh, Umashankar | en_US |
dc.contributor.author | Yu, Yang | en_US |
dc.contributor.author | Ellsworth, Buffy S. | en_US |
dc.contributor.author | Hemberger, Myriam | en_US |
dc.contributor.author | Geyer, Rudolf | en_US |
dc.contributor.author | Stewart, M. David | en_US |
dc.contributor.author | Behringer, Richard R. | en_US |
dc.contributor.author | Fundele, Reinald | en_US |
dc.date.accessioned | 2008-05-12T13:40:25Z | |
dc.date.available | 2009-05-04T19:09:21Z | en_US |
dc.date.issued | 2008-05 | en_US |
dc.identifier.citation | Tian, Geng; Singh, Umashankar; Yu, Yang; Ellsworth, Buffy S.; Hemberger, Myriam; Geyer, Rudolf; Stewart, M. David; Behringer, Richard R.; Fundele, Reinald (2008). "Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta." Developmental Dynamics 237(5): 1517-1525. <http://hdl.handle.net/2027.42/58577> | en_US |
dc.identifier.issn | 1058-8388 | en_US |
dc.identifier.issn | 1097-0177 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/58577 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18425848&dopt=citation | |
dc.description.abstract | The LIM homeobox containing genes of the LIM-3 group, Lhx3 and Lhx4 , are critical for normal development. Both genes are involved in the formation of the pituitary and the motoneuron system and loss of either gene causes perinatal lethality. Previous studies had shown that Lhx3 is overexpressed in hyperplastic placentas of mouse interspecies hybrids. To determine the role of LHX3 in the mouse placenta, we performed expression and function analyses. Our results show that Lhx3 exhibits specific spatial and temporal expression in the mouse placenta. However, deletion of Lhx3 does not produce a placental phenotype. To test whether this is due to functional substitution by Lhx4 , we performed a phenotype analysis of Lhx3 −/−; Lhx4 −/− double-mutant placentas. A subset of Lhx3 −/−; Lhx4 −/− placentas exhibited abnormal structure of the labyrinth. However, absence of both LIM-3 genes did not interfere with placental transport nor consistently with expression of target genes such as Gnrhr . Thus, LHX3 and LHX4 appear to be dispensable for placental development and function. Developmental Dynamics 237:1517-1525, 2008. © 2008 Wiley-Liss, Inc. | en_US |
dc.format.extent | 293822 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley-Liss, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Department of Animal Genetics and Development, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden ; Geng Tian, Umashankar Singh, and Yang Yu contributed equally to this work. | en_US |
dc.contributor.affiliationother | Department of Animal Genetics and Development, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden | en_US |
dc.contributor.affiliationother | Department of Animal Genetics and Development, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden | en_US |
dc.contributor.affiliationother | Laboratory for Developmental Genetics & Imprinting, Babraham Institute, Cambridge, United Kingdom | en_US |
dc.contributor.affiliationother | Institute of Biochemistry, Faculty of Medicine, Justus-Liebig-University Giessen, Giessen, Germany | en_US |
dc.contributor.affiliationother | Department of Molecular Genetics, The University of Texas, M.D. Anderson Cancer Center, Houston Texas | en_US |
dc.contributor.affiliationother | Department of Molecular Genetics, The University of Texas, M.D. Anderson Cancer Center, Houston Texas | en_US |
dc.contributor.affiliationother | Department of Animal Genetics and Development, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden ; NorbyvÄgen 18A, Uppsala, 75236 Sweden | en_US |
dc.identifier.pmid | 18425848 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/58577/1/21546_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/dvdy.21546 | en_US |
dc.identifier.source | Developmental Dynamics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.