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| Title: | Temporal Coherence in Ultradian Sleep EEG Rhythms |
| Authors: | Morehouse, Rachel
Kusumakar, Vivek
Kutcher, Stanley
LeBlanc, John
Armitage, Roseanne |
| Keywords: | Adolescents
Depression |
| Issue Date: | 2002 |
| Citation: | Biological Psychiatry, 2002, 51(6), 446-456 <http://hdl.handle.net/2027.42/60181> |
| Abstract: | Background: Previous work has indicated that low temporal
coherence of ultradian sleep electroencephalographic
rhythms is characteristic of depressed patients
and of depressed women, in particular. It may also be
evident in one quarter of those at high risk, based on a
family history of depression.
Methods: The present study evaluated temporal coherence
of sleep electroencephalographic rhythms in 41
adolescent girls with a maternal history of depression
(high risk) and 40 healthy controls (low risk). The entire
sample was followed clinically every 6 months for 2 years.
Results: Temporal coherence was significantly lower
among the high-risk girls than in controls. Regression
analyses predicted group from coherence values and
correctly classified 70% of the high-risk group with a
false-positive rate of 5% among controls. Moreover, 54%
of the high-risk girls were identified with extreme low
coherence. On clinical follow up, 14 girls showed depressive
symptoms, 9 in the high-risk group (22.5%) and 5
controls (12.2%). Six met DSM-IV criteria for firstepisode
major depressive disorder, five high-risk and one
control. Most importantly, 41% of those identified as
having the most abnormal coherence values either showed
symptoms of depression or met diagnostic criteria upon
follow up.
Conclusions: Low temporal coherence is evident in adolescent
girls at high risk for depression. The more abnormal
the coherence, the greater the risk of a first episode of
major depressive disorder within 2 years of sleep study,
approximately 10 times greater than in controls. Biol
Psychiatry 2002;51:446–456 © 2002 Society of Biological
Psychiatry |
| Appears in Collections: | Psychiatry, Department of
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| Morehouse, 2002.pdf | | 90Kb | Adobe PDF | View/Open |
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