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| Title: | The Neurobiology of Depression: Perspectives |
| Authors: | Shaffery, James
Hoffmann, Robert
Armitage, Roseanne |
| Keywords: | Depression
Sex Differences |
| Issue Date: | 2003 |
| Publisher: | Sage |
| Citation: | The Neuroscientist, 2003, 9(1). 82-98 <http://hdl.handle.net/2027.42/60184> |
| Abstract: | This article reviews human and animal studies in the neurobiology of depression. The etiology of the illness,
associated neurotransmitter dysregulation, sex steroids, the role of stress, and sleep regulation are discussed.
It is suggested that the genesis of depression is related to homeostatic maladaptation that is sexually
dimorphic. The authors propose that depressed females are hyperresponsive to stress, whereas
depressed males are hyporesponsive to stress. This divergence reflects the exaggeration of naturally
occurring differences between males and females, which are most obvious under challenge conditions. The
authors conclude that future work in this area should fully evaluate sexual dimorphism, neural plasticity, critical
periods, and individual differences in vulnerability. NEUROSCIENTIST 9(1):82–98, 2003. DOI: 10.1177/
1073858402239594 |
| Appears in Collections: | Psychiatry, Department of
Interdisciplinary and Peer-Reviewed
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| shaffery.pdf | | 159Kb | Adobe PDF | View/Open |
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