Preoperative assessment enables the early diagnosis and successful treatment of lymphedema.
dc.contributor.author | Stout Gergich, Nicole L. | en_US |
dc.contributor.author | Pfalzer, Lucinda A. | en_US |
dc.contributor.author | McGarvey, Charles | en_US |
dc.contributor.author | Springer, Barbara | en_US |
dc.contributor.author | Gerber, Lynn H. | en_US |
dc.contributor.author | Soballe, Peter | en_US |
dc.date.accessioned | 2008-07-01T14:06:47Z | |
dc.date.available | 2009-07-06T16:34:52Z | en_US |
dc.date.issued | 2008-06-15 | en_US |
dc.identifier.citation | Stout Gergich, Nicole L.; Pfalzer, Lucinda A.; McGarvey, Charles; Springer, Barbara; Gerber, Lynn H.; Soballe, Peter (2008). "Preoperative assessment enables the early diagnosis and successful treatment of lymphedema." Cancer 112(12): 2809-2819. <http://hdl.handle.net/2027.42/60215> | en_US |
dc.identifier.issn | 0008-543X | en_US |
dc.identifier.issn | 1097-0142 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/60215 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18428212&dopt=citation | en_US |
dc.description.abstract | BACKGROUND The incidence of breast cancer (BC)-related lymphedema (LE) ranges from 7% to 47%. Successful management of LE relies on early diagnosis using sensitive measurement techniques. In the current study, the authors demonstrated the effectiveness of a surveillance program that included preoperative limb volume measurement and interval postoperative follow-up to detect and treat subclinical LE. METHODS LE was identified in 43 of 196 women who participated in a prospective BC morbidity trial. Limb volume was measured preoperatively and at 3-month intervals after surgery. If an increase >3% in upper limb (UL) volume developed compared with the preoperative volume, then a diagnosis of LE was made, and a compression garment intervention was prescribed for 4 weeks. Upon reduction of LE, garment wear was continued only during strenuous activity, with symptoms of heaviness, or with visible swelling. Women returned to the 3-month interval surveillance pathway. Statistical analysis was a repeated-measures analysis of variance by time and limb ( P ≤ .001) comparing the LE cohort with an age-matched control group. RESULTS The time to onset of LE averaged 6.9 months postoperatively. The mean (±standard deviation) affected limb volume increase was 83 mL (±119 mL; 6.5% ± 9.9%) at LE onset ( P = .005) compared with baseline. After the intervention, a statistically significant mean 48 mL (±103 mL; 4.1% ± 8.8%) volume decrease was realized ( P < .0001). The mean duration of the intervention was 4.4 weeks (±2.9 weeks). Volume reduction was maintained at an average follow-up of 4.8 months (±4.1 months) after the intervention. CONCLUSIONS A short trial of compression garments effectively treated subclinical LE. Cancer 2008. Published 2008 by the American Cancer Society. | en_US |
dc.format.extent | 425450 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Preoperative assessment enables the early diagnosis and successful treatment of lymphedema. | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Physical Therapy Department, University of Michigan-Flint, Flint, Michigan | en_US |
dc.contributor.affiliationother | Breast Cancer Department, National Naval Medical Center, Bethesda, Maryland ; Fax: (301) 295-9076. ; CLT-LANA, National Naval Medical Center, 8901 Wisconsin Avenue, Building 10, Breast Care Center, fourth Floor West, Bethesda, MD 20889-5600 | en_US |
dc.contributor.affiliationother | Rehabilitation Medicine Department, National Institutes of Health, Bethesda, Maryland | en_US |
dc.contributor.affiliationother | Physical Therapy Department, Walter Reed Army Medical Center, Bethesda, Maryland | en_US |
dc.contributor.affiliationother | College of Health and Human Services, George Mason University, Fairfax, Virginia | en_US |
dc.contributor.affiliationother | Breast Cancer Department, National Naval Medical Center, Bethesda, Maryland | en_US |
dc.identifier.pmid | 18428212 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/60215/1/23494_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/cncr.23494 | en_US |
dc.identifier.source | Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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