Systematic comparison of the human saliva and plasma proteomes
dc.contributor.author | Yan, Weihong | en_US |
dc.contributor.author | Apweiler, Rolf | en_US |
dc.contributor.author | Balgley, Brian M. | en_US |
dc.contributor.author | Boontheung, Pinmanee | en_US |
dc.contributor.author | Bundy, Jonathan L. | en_US |
dc.contributor.author | Cargile, Benjamin J. | en_US |
dc.contributor.author | Cole, Steve | en_US |
dc.contributor.author | Fang, Xueping | en_US |
dc.contributor.author | Gonzalez-Begne, Mireya | en_US |
dc.contributor.author | Griffin, Timothy J. | en_US |
dc.contributor.author | Hagen, Fred | en_US |
dc.contributor.author | Hu, Shen | en_US |
dc.contributor.author | Wolinsky, Lawrence E. | en_US |
dc.contributor.author | Lee, Cheng S. | en_US |
dc.contributor.author | Malamud, Daniel | en_US |
dc.contributor.author | Melvin, James E. | en_US |
dc.contributor.author | Menon, Rajasree | en_US |
dc.contributor.author | Mueller, Michael | en_US |
dc.contributor.author | Qiao, Renli | en_US |
dc.contributor.author | Rhodus, Nelson L. | en_US |
dc.contributor.author | Sevinsky, Joel R. | en_US |
dc.contributor.author | States, David J. | en_US |
dc.contributor.author | Stephenson, James L. | en_US |
dc.contributor.author | Than, Shawn | en_US |
dc.contributor.author | Yates, John R. | en_US |
dc.contributor.author | Yu, Weixia | en_US |
dc.contributor.author | Xie, Hongwei | en_US |
dc.contributor.author | Xie, Yongming | en_US |
dc.contributor.author | Omenn, Gilbert S. | en_US |
dc.contributor.author | Loo, Joseph A. | en_US |
dc.contributor.author | Wong, David T. | en_US |
dc.date.accessioned | 2009-02-03T16:16:42Z | |
dc.date.available | 2010-03-01T21:10:28Z | en_US |
dc.date.issued | 2009-01 | en_US |
dc.identifier.citation | Yan, Weihong; Apweiler, Rolf; Balgley, Brian M.; Boontheung, Pinmanee; Bundy, Jonathan L.; Cargile, Benjamin J.; Cole, Steve; Fang, Xueping; Gonzalez-Begne, Mireya; Griffin, Timothy J.; Hagen, Fred; Hu, Shen; Wolinsky, Lawrence E.; Lee, Cheng S.; Malamud, Daniel; Melvin, James E.; Menon, Rajasree; Mueller, Michael; Qiao, Renli; Rhodus, Nelson L.; Sevinsky, Joel R.; States, David; Stephenson, James L.; Than, Shawn; Yates, John R.; Yu, Weixia; Xie, Hongwei; Xie, Yongming; Omenn, Gilbert S.; Loo, Joseph A.; Wong, David T. (2009). "Systematic comparison of the human saliva and plasma proteomes." PROTEOMICS - Clinical Applications 3(1): 116-134. <http://hdl.handle.net/2027.42/61527> | en_US |
dc.identifier.issn | 1862-8346 | en_US |
dc.identifier.issn | 1862-8354 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/61527 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=19898684&dopt=citation | en_US |
dc.description.abstract | The proteome of human salivary fluid has the potential to open new doors for disease biomarker discovery. A recent study to comprehensively identify and catalog the human ductal salivary proteome led to the compilation of 1166 proteins. The protein complexity of both saliva and plasma is large, suggesting that a comparison of these two proteomes will provide valuable insight into their physiological significance and an understanding of the unique and overlapping disease diagnostic potential that each fluid provides. To create a more comprehensive catalog of human salivary proteins, we have first compiled an extensive list of proteins from whole saliva (WS) identified through MS experiments. The WS list is thereafter combined with the proteins identified from the ductal parotid, and submandibular and sublingual (parotid/SMSL) salivas. In parallel, a core dataset of the human plasma proteome with 3020 protein identifications was recently released. A total of 1939 nonredundant salivary proteins were compiled from a total of 19 14474 unique peptide sequences identified from whole and ductal salivas[semi] 740 out of the total 1939 salivary proteins were identified in both whole and ductal saliva. A total of 597 of the salivary proteins have been observed in plasma. Gene ontology (GO) analysis showed similarities in the distributions of the saliva and plasma proteomes with regard to cellular localization, biological processes, and molecular function, but revealed differences which may be related to the different physiological functions of saliva and plasma. The comprehensive catalog of the salivary proteome and its comparison to the plasma proteome provides insights useful for future study, such as exploration of potential biomarkers for disease diagnostics. | en_US |
dc.format.extent | 43745 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | WILEY-VCH Verlag | en_US |
dc.subject.other | Life Sciences | en_US |
dc.subject.other | Molecular Cell Biology | en_US |
dc.title | Systematic comparison of the human saliva and plasma proteomes | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Medicine and Genetics and Center for Computational Medicine and Biology, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Departments of Medicine and Genetics and Center for Computational Medicine and Biology, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Departments of Medicine and Genetics and Center for Computational Medicine and Biology, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, CA, USA | en_US |
dc.contributor.affiliationother | EMBL Outstation, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK | en_US |
dc.contributor.affiliationother | Calibrant Biosystems, Gaithersburg, MD, USA | en_US |
dc.contributor.affiliationother | Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, CA, USA | en_US |
dc.contributor.affiliationother | Biomarkers and Systems Biology Center, Research Triangle Institute, Research Triangle, NC, USA | en_US |
dc.contributor.affiliationother | Biomarkers and Systems Biology Center, Research Triangle Institute, Research Triangle, NC, USA | en_US |
dc.contributor.affiliationother | UCLA School of Dentistry and UCLA Dental Research Institute, University of California-Los Angeles, Los Angeles, CA, USA | en_US |
dc.contributor.affiliationother | Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA | en_US |
dc.contributor.affiliationother | Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA | en_US |
dc.contributor.affiliationother | Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA | en_US |
dc.contributor.affiliationother | Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA | en_US |
dc.contributor.affiliationother | UCLA School of Dentistry and UCLA Dental Research Institute, University of California-Los Angeles, Los Angeles, CA, USA | en_US |
dc.contributor.affiliationother | UCLA School of Dentistry and UCLA Dental Research Institute, University of California-Los Angeles, Los Angeles, CA, USA | en_US |
dc.contributor.affiliationother | Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA | en_US |
dc.contributor.affiliationother | College of Dentistry, New York University, New York, NY, USA | en_US |
dc.contributor.affiliationother | Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA | en_US |
dc.contributor.affiliationother | EMBL Outstation, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK | en_US |
dc.contributor.affiliationother | Division of Pulmonary and Critical Care Medicine, University of Southern California, Los Angeles, CA, USA | en_US |
dc.contributor.affiliationother | Department of Oral Medicine, Diagnosis, and Radiology, School of Dentistry, University of Minnesota, Minneapolis, MN, USA | en_US |
dc.contributor.affiliationother | Biomarkers and Systems Biology Center, Research Triangle Institute, Research Triangle, NC, USA | en_US |
dc.contributor.affiliationother | Biomarkers and Systems Biology Center, Research Triangle Institute, Research Triangle, NC, USA | en_US |
dc.contributor.affiliationother | UCLA School of Dentistry and UCLA Dental Research Institute, University of California-Los Angeles, Los Angeles, CA, USA | en_US |
dc.contributor.affiliationother | Scripps Research Institute, La Jolla, CA, USA | en_US |
dc.contributor.affiliationother | UCLA School of Dentistry and UCLA Dental Research Institute, University of California-Los Angeles, Los Angeles, CA, USA | en_US |
dc.contributor.affiliationother | Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA | en_US |
dc.contributor.affiliationother | Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, CA, USA | en_US |
dc.contributor.affiliationother | Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, CA, USA ; Department of Biological Chemistry, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA ; Additional corresponding author | en_US |
dc.contributor.affiliationother | UCLA School of Dentistry and UCLA Dental Research Institute, University of California-Los Angeles, Los Angeles, CA, USA ; University of California-Los Angeles, School of Dentistry, 73-017 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA Fax: +1-310-825-7609 | en_US |
dc.identifier.pmid | 19898684 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/61527/1/prca_200800140_sm_miscellaneous_information.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/prca.200800140 | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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