Show simple item record

Effects of delayed treatment with combined GDNF and continuous electrical stimulation on spiral ganglion cell survival in deafened guinea pigs

dc.contributor.authorScheper, Verenaen_US
dc.contributor.authorPaasche, Gerriten_US
dc.contributor.authorMiller, Josef M.en_US
dc.contributor.authorWarnecke, Athanasiaen_US
dc.contributor.authorBerkingali, Nurdanaten_US
dc.contributor.authorLenarz, Thomasen_US
dc.contributor.authorStöver, Timoen_US
dc.date.accessioned2009-04-09T14:41:06Z
dc.date.available2010-07-06T14:30:31Zen_US
dc.date.issued2009-05-01en_US
dc.identifier.citationScheper, Verena; Paasche, Gerrit; Miller, Josef M.; Warnecke, Athanasia; Berkingali, Nurdanat; Lenarz, Thomas; StÖver, Timo (2009). "Effects of delayed treatment with combined GDNF and continuous electrical stimulation on spiral ganglion cell survival in deafened guinea pigs." Journal of Neuroscience Research 87(6): 1389-1399. <http://hdl.handle.net/2027.42/62037>en_US
dc.identifier.issn0360-4012en_US
dc.identifier.issn1097-4547en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/62037
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=19084902&dopt=citationen_US
dc.description.abstractElectrical stimulation (ES) of spiral ganglion cells (SGC) via a cochlear implant is the standard treatment for profound sensor neural hearing loss. However, loss of hair cells as the morphological correlate of sensor neural hearing loss leads to deafferentation and death of SGC. Although immediate treatment with ES or glial cell line–derived neurotrophic factor (GDNF) can prevent degeneration of SGC, only few studies address the effectiveness of delayed treatment. We hypothesize that both interventions have a synergistic effect and that even delayed treatment would protect SGC. Therefore, an electrode connected to a pump was implanted into the left cochlea of guinea pigs 3 weeks after deafening. The contralateral untreated cochleae served as deafened intraindividual controls. Four groups were set up. Control animals received intracochlear infusion of artificial perilymph (AP/−). The experimental groups consisted of animals treated with AP in addition to continuous ES (AP/ES) or treated with GDNF alone (GDNF/−) or GDNF combined with continuous ES (GDNF/ES). Acoustically and electrically evoked auditory brain stem responses were recorded. All animals were killed 48 days after deafening; their cochleae were histologically evaluated. Survival of SGC increased significantly in the GDNF/− and AP/ES group compared with the AP/− group. A highly significant increase in SGC density was observed in the GDNF/ES group compared with the control group. Additionally, animals in the GDNF/ES group showed reduced EABR thresholds. Thus, delayed treatment with GDNF and ES can protect SGC from degeneration and may improve the benefits of cochlear implants. © 2008 Wiley-Liss, Inc.en_US
dc.format.extent495617 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology and Psychiatryen_US
dc.titleEffects of delayed treatment with combined GDNF and continuous electrical stimulation on spiral ganglion cell survival in deafened guinea pigsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelPsychologyen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelSocial Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumKresge Hearing Research Institute, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationotherDepartment of Otolaryngology, Medical University Hannover, Hannover, Germany ; Department of Otolaryngology, Medical University Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germanyen_US
dc.contributor.affiliationotherDepartment of Otolaryngology, Medical University Hannover, Hannover, Germanyen_US
dc.contributor.affiliationotherDepartment of Otolaryngology, Medical University Hannover, Hannover, Germanyen_US
dc.contributor.affiliationotherDepartment of Otolaryngology, Medical University Hannover, Hannover, Germanyen_US
dc.contributor.affiliationotherDepartment of Otolaryngology, Medical University Hannover, Hannover, Germanyen_US
dc.contributor.affiliationotherDepartment of Otolaryngology, Medical University Hannover, Hannover, Germanyen_US
dc.identifier.pmid19084902en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/62037/1/21964_ftp.pdf
dc.identifier.doi10.1002/jnr.21964en_US
dc.identifier.sourceJournal of Neuroscience Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.