Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition
dc.contributor.author | Muotri, A. R. | en_US |
dc.contributor.author | Chu, Vi T. | en_US |
dc.contributor.author | Marchetto, M. C. N. | en_US |
dc.contributor.author | Deng, W. | en_US |
dc.contributor.author | Moran, J. V. | en_US |
dc.contributor.author | Gage, Fred H. | en_US |
dc.date.accessioned | 2009-06-01T17:33:14Z | |
dc.date.available | 2009-06-01T17:33:14Z | |
dc.date.issued | 2005-06-16 | en_US |
dc.identifier.citation | Muotri, AR; Chu, VT; Marchetto, MCN; Deng, W; Moran, JV; Gage, FH. (2005) "Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition." Nature 435(7044): 903-910. <http://hdl.handle.net/2027.42/62714> | en_US |
dc.identifier.issn | 0028-0836 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/62714 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15959507&dopt=citation | en_US |
dc.description.abstract | Revealing the mechanisms for neuronal somatic diversification remains a central challenge for understanding individual differences in brain organization and function. Here we show that an engineered human LINE-1 (for long interspersed nuclear element-1; also known as L1) element can retrotranspose in neuronal precursors derived from rat hippocampus neural stem cells. The resulting retrotransposition events can alter the expression of neuronal genes, which, in turn, can influence neuronal cell fate in vitro. We further show that retrotransposition of a human L1 in transgenic mice results in neuronal somatic mosaicism. The molecular mechanism of action is probably mediated through Sox2, because a decrease in Sox2 expression during the early stages of neuronal differentiation is correlated with increases in both L1 transcription and retrotransposition. Our data therefore indicate that neuronal genomes might not be static, but some might be mosaic because of de novo L1 retrotransposition events. | en_US |
dc.format.extent | 508370 bytes | |
dc.format.extent | 2489 bytes | |
dc.format.mimetype | application/octet-stream | |
dc.format.mimetype | text/plain | |
dc.publisher | Nature Publishing Group | en_US |
dc.source | Nature | en_US |
dc.title | Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Univ Michigan, Sch Med, Dept Human Genet & Internal Med, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationother | Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA | en_US |
dc.identifier.pmid | 15959507 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/62714/1/nature03663.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1038/nature03663 | en_US |
dc.identifier.source | Nature | en_US |
dc.contributor.authoremail | gage@salk.edu | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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