Protective Effects Of Oligosaccharides In P-selectin-dependent Lung Injury
dc.contributor.author | Mulligan, Michael S. | en_US |
dc.contributor.author | Paulson, James C. | en_US |
dc.contributor.author | Defrees, S. | en_US |
dc.contributor.author | Zheng, Z. L. | en_US |
dc.contributor.author | Lowe, John B. | en_US |
dc.contributor.author | Ward, Peter A. | en_US |
dc.date.accessioned | 2009-06-01T17:33:51Z | |
dc.date.available | 2009-06-01T17:33:51Z | |
dc.date.issued | 1993-07-08 | en_US |
dc.identifier.citation | Mulligan, MS; Paulson, JC; Defrees, S; Zheng, ZL; Lowe, JB; Ward, PA. (1993) "Protective Effects Of Oligosaccharides In P-selectin-dependent Lung Injury." Nature 364(6433): 149-151. <http://hdl.handle.net/2027.42/62725> | en_US |
dc.identifier.issn | 0028-0836 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/62725 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7686631&dopt=citation | en_US |
dc.description.abstract | NEUTROPHIL recruitment into tissues is a multistep process involving sequential engagement of adhesion molecules, including selectins (E,P,L), which are reactive with oligosaccharides, and the family of beta2 integrins which are reactive with endothelial intercellular adhesion molecules1-3. These processes result in the initial rolling of leukocytes along the endothelial surfaces, followed by the firm attachment of leukocytes to the endothelium. The intravenous infusion of cobra venom factor into rats results in acute lung injury that is neutrophil-dependent, oxygen radical mediated and P-selectin-dependent4,5. Here we report that infusion of sialyl-Lewis X, a ligand for P-selectin6-9, dramatically reduced lung injury and diminished the tissue accumulation of neutrophils, whereas irrelevant oligosaccharides had no such effects. These results suggest that sialyl-Lewis X carbohydrates maybe used as a new strategy for anti-inflammatory therapy. | en_US |
dc.format.extent | 444257 bytes | |
dc.format.extent | 2489 bytes | |
dc.format.mimetype | application/octet-stream | |
dc.format.mimetype | text/plain | |
dc.publisher | Macmillan Magazines Ltd. | en_US |
dc.source | Nature | en_US |
dc.title | Protective Effects Of Oligosaccharides In P-selectin-dependent Lung Injury | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | UNIV MICHIGAN,SCH MED,DEPT PATHOL,1301 CATHERINE RD,ANN ARBOR,MI 48109 | en_US |
dc.contributor.affiliationum | UNIV MICHIGAN,SCH MED,HOWARD HUGHES MED INST,ANN ARBOR,MI 48109 | en_US |
dc.contributor.affiliationother | CYTEL CORP,SAN DIEGO,CA 92121 | en_US |
dc.identifier.pmid | 7686631 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/62725/1/364149a0.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1038/364149a0 | en_US |
dc.identifier.source | Nature | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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