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Cancer Gene Therapy Using Plasmid DNA: Pharmacokinetic Study of DNA Following Injection in Mice

dc.contributor.authorLew, Deniseen_US
dc.contributor.authorParker, Suezanne E.en_US
dc.contributor.authorLatimer, Terrieen_US
dc.contributor.authorAbai, Anna M.en_US
dc.contributor.authorKuwahara-Rundell, Annen_US
dc.contributor.authorDoh, Soeun Graceen_US
dc.contributor.authorYang, Zhi-Yongen_US
dc.contributor.authorLaface, Drakeen_US
dc.contributor.authorGromkowski, Stanislaw H.en_US
dc.contributor.authorNabel, Gary J.en_US
dc.contributor.authorManthorpe, Marstonen_US
dc.contributor.authorNorman, Jonen_US
dc.date.accessioned2009-07-10T18:59:33Z
dc.date.available2009-07-10T18:59:33Z
dc.date.issued1995-05-01en_US
dc.identifier.citationLew, Denise; Parker, Suezanne E.; Latimer, Terrie; Abai, Anna M.; Kuwahara-Rundell, Ann; Doh, Soeun Grace; Yang, Zhi-Yong; Laface, Drake; Gromkowski, Stanislaw H.; Nabel, Gary J.; Manthorpe, Marston; Norman, Jon (1995). "Cancer Gene Therapy Using Plasmid DNA: Pharmacokinetic Study of DNA Following Injection in Mice." Human Gene Therapy 6(5): 553-564 <http://hdl.handle.net/2027.42/63149>en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/63149
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7578393&dopt=citationen_US
dc.description.abstractOverview summary The present study evaluates the pharmacokinetic half-life and tissue distribution of plasmid DNA following intravenous injection in mice. This study extends the time frame of previous in vivo analyses to 6 months following i.v. injection. Injected mice exhibit no expression of the encoded gene as assayed by immunofluorescence. This represents the first systematic in vivo pharmacokinetic study of intravenously injected DNA complexed with cationic lipids, and is relevant to many gene therapy protocols utilizing direct injection of plasmid DNA plus lipids. The results provide a preliminary basis for the safe initiation of cancer immunotherapy clinical trials in which plasmid DNA is directly injected into tumors.en_US
dc.format.extent3048703 bytes
dc.format.extent2489 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherMary Ann Liebert, Inc., publishersen_US
dc.titleCancer Gene Therapy Using Plasmid DNA: Pharmacokinetic Study of DNA Following Injection in Miceen_US
dc.typeArticleen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.identifier.pmid7578393en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/63149/1/hum.1995.6.5-553.pdf
dc.identifier.doidoi:10.1089/hum.1995.6.5-553en_US
dc.identifier.sourceHuman Gene Therapyen_US
dc.identifier.sourceHuman Gene Therapyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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