HIV Genetic Diversity in Cameroon: Possible Public Health Importance
dc.contributor.author | Ndongmo, Clement B. | en_US |
dc.contributor.author | Pieniazek, Danuta | en_US |
dc.contributor.author | Holberg-Petersen, Mona | en_US |
dc.contributor.author | Holm-Hansen, Carol | en_US |
dc.contributor.author | Zekeng, Leopold | en_US |
dc.contributor.author | Jeansson, Stig L. | en_US |
dc.contributor.author | Kaptue, Lazare | en_US |
dc.contributor.author | Kalish, Marcia L. | en_US |
dc.date.accessioned | 2009-07-10T18:59:36Z | |
dc.date.available | 2009-07-10T18:59:36Z | |
dc.date.issued | 2006-08-01 | en_US |
dc.identifier.citation | Ndongmo, Clement B.; Pieniazek, Danuta; Holberg-Petersen, Mona; Holm-Hansen, Carol; Zekeng, Leopold; Jeansson, Stig L.; Kaptue, Lazare; Kalish, Marcia L. (2006). "HIV Genetic Diversity in Cameroon: Possible Public Health Importance." AIDS Research and Human Retroviruses 22(8): 812-816 <http://hdl.handle.net/2027.42/63150> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/63150 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16910839&dopt=citation | en_US |
dc.description.abstract | To monitor the evolving molecular epidemiology and genetic diversity of HIV in a country where many distinct strains cocirculate, we performed genetic analyses on sequences from 75 HIV-1-infected Cameroonians: 74 were group M and 1 was group O. Of the group M sequences, 74 were classified into the following env gp41 subtypes or recombinant forms: CRF02 (n = 54), CRF09 (n = 2), CRF13 (n = 2), A (n = 5), CRF11 (n = 4), CRF06 (n = 1), G (n = 2), F2 (n = 2), and E (n = 1, CRF01), and 1 was a JG recombinant. Comparison of phylogenies for 70 matched gp41 and protease sequences showed inconsistent classifications for 18 (26%) strains. Our data show that recombination is rampant in Cameroon with recombinant viruses continuing to recombine, adding to the complexity of circulating HIV strains. This expanding genetic diversity raises public health concerns for the ability of diagnostic assays to detect these unique HIV mosaic variants and for the development of broadly effective HIV vaccines. | en_US |
dc.format.extent | 447657 bytes | |
dc.format.extent | 2489 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Mary Ann Liebert, Inc., publishers | en_US |
dc.title | HIV Genetic Diversity in Cameroon: Possible Public Health Importance | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.identifier.pmid | 16910839 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/63150/1/aid.2006.22.812.pdf | |
dc.identifier.doi | doi:10.1089/aid.2006.22.812 | en_US |
dc.identifier.source | AIDS Research and Human Retroviruses | en_US |
dc.identifier.source | AIDS Research and Human Retroviruses | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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