Pulmonary Inflammation Induced by Incomplete or Inactivated Adenoviral Particles

McCoy, Ronald D.; Davidson, Beverly L.; Roessler, Blake J.; Huffnagle, Gary B.; Janich, Sonia L.; Laing, Timothy J.; Simon, Richard H.

1995-12-01

Citation: McCoy, Ronald D.; Davidson, Beverly L.; Roessler, Blake J.; Huffnagle, Gary B.; Janich, Sonia L.; Laing, Timothy J.; Simon, Richard H. (1995). "Pulmonary Inflammation Induced by Incomplete or Inactivated Adenoviral Particles." Human Gene Therapy 6(12): 1553-1560 <http://hdl.handle.net/2027.42/63169>

Abstract: Overview summary The amount of pulmonary inflammation induced in mice by intratracheal administration of high doses of adenoviral vectors was compared to that induced by viral particles that lack the ability to express the genes that they contain. The number of inflammatory cells infiltrating the lung 6 days after particle administration was similar between animals receiving normal versus defective adenoviral particles.

DOIs: doi:10.1089/hum.1995.6.12-1553

PMID: 8664380

URI: http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8664380&dopt=citation

Handle: http://hdl.handle.net/2027.42/63169

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