Safety and Toxicity of Catheter Gene Delivery to the Pulmonary Vasculature in a Patient with Metastatic Melanoma

Nabel, Elizabeth G.; Yang, Zhiyong; Muller, David; Chang, Alfred E.; Gao, Xiang; Huang, Leaf; Cho, Kyung J.; Nabel, Gary J.

1994-09-01

Citation: Nabel, Elizabeth G.; Yang, Zhiyong; Muller, David; Chang, Alfred E.; Gao, Xiang; Huang, Leaf; Cho, Kyung J.; Nabel, Gary J. (1994). "Safety and Toxicity of Catheter Gene Delivery to the Pulmonary Vasculature in a Patient with Metastatic Melanoma." Human Gene Therapy 5(9): 1089-1094 <http://hdl.handle.net/2027.42/63196>

Abstract: Overview summary Transcatheter delivery of HLA-B7 DNA and cationic liposomes into a segment of a pulmonary artery was safely performed in 1 patient with tumor nodules in the lung. No immunologic or organ toxicities were observed. Percutaneous catheter gene delivery has been performed in humans. Further refinements of this approach may lead to useful treatments for a variety of human diseases.

DOIs: doi:10.1089/hum.1994.5.9-1089

PMID: 7833368

URI: http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7833368&dopt=citation

Handle: http://hdl.handle.net/2027.42/63196

Show full item record