Genetic Modification of Human Peripheral Blood Lymphocytes with a Transdominant Negative Form of Rev: Safety and Toxicity
dc.contributor.author | Fox, Bernard A. | en_US |
dc.contributor.author | Woffendin, Clive | en_US |
dc.contributor.author | Yang, Zhi-Yong | en_US |
dc.contributor.author | San, Hong | en_US |
dc.contributor.author | Ranga, Udaykumar | en_US |
dc.contributor.author | Gordon, David | en_US |
dc.contributor.author | Osterholzer, John | en_US |
dc.contributor.author | Nabel, Gary J. | en_US |
dc.date.accessioned | 2009-07-10T19:04:18Z | |
dc.date.available | 2009-07-10T19:04:18Z | |
dc.date.issued | 1995-08-01 | en_US |
dc.identifier.citation | Fox, Bernard A.; Woffendin, Clive; Yang, Zhi-Yong; San, Hong; Ranga, Udaykumar; Gordon, David; Osterholzer, John; Nabel, Gary J. (1995). "Genetic Modification of Human Peripheral Blood Lymphocytes with a Transdominant Negative Form of Rev: Safety and Toxicity." Human Gene Therapy 6(8): 997-1004 <http://hdl.handle.net/2027.42/63234> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/63234 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7578421&dopt=citation | en_US |
dc.description.abstract | Overview summary Expression of Rev M10, a transdominant mutant form of the Rev gene, in T cell lines confers resistance to HIV in vitro. Isertion of this Rev M10 gene into PBL appears to be nontoxic and well-tolerated by SCID mice. These results demonstrate that genetic modification of T cells by an antiviral gene can be performed safely and without overt toxicity. This finding encourages the development of therapeutic strategies to genetically protect T cells to prolong their survival in HIV-infected individuals. | en_US |
dc.format.extent | 1210926 bytes | |
dc.format.extent | 2489 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Mary Ann Liebert, Inc., publishers | en_US |
dc.title | Genetic Modification of Human Peripheral Blood Lymphocytes with a Transdominant Negative Form of Rev: Safety and Toxicity | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.identifier.pmid | 7578421 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/63234/1/hum.1995.6.8-997.pdf | |
dc.identifier.doi | doi:10.1089/hum.1995.6.8-997 | en_US |
dc.identifier.source | Human Gene Therapy | en_US |
dc.identifier.source | Human Gene Therapy | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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