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A Method of Limited Replication for the Efficient In Vivo Delivery of Adenovirus to Cancer Cells

dc.contributor.authorHan, Jeffrey S.en_US
dc.contributor.authorQian, Dalongen_US
dc.contributor.authorWicha, Max S.en_US
dc.contributor.authorClarke, Michael F.en_US
dc.date.accessioned2009-07-10T19:06:55Z
dc.date.available2009-07-10T19:06:55Z
dc.date.issued1998-05-20en_US
dc.identifier.citationHan, Jeffrey S.; Qian, Dalong; Wicha, Max S.; Clarke, Michael F. (1998). "A Method of Limited Replication for the Efficient In Vivo Delivery of Adenovirus to Cancer Cells." Human Gene Therapy 9(8): 1209-1216 <http://hdl.handle.net/2027.42/63280>en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/63280
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9625260&dopt=citationen_US
dc.description.abstractOverview summary Replication-defective viral vectors are limited in their ability to diffuse through tissue. This poses a problem for treating tumors in vivo using gene transfer. This article demonstrates that limited replication of adenovirus leads to greater gene transfer efficiency in vitro and in vivo without introducing additional safety concerns beyond traditional adenovirus administration. This has implications for the improvement of current gene transfer methods for treating cancer.en_US
dc.format.extent2647119 bytes
dc.format.extent2489 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherMary Ann Liebert, Inc., publishersen_US
dc.titleA Method of Limited Replication for the Efficient In Vivo Delivery of Adenovirus to Cancer Cellsen_US
dc.typeArticleen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.identifier.pmid9625260en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/63280/1/hum.1998.9.8-1209.pdf
dc.identifier.doidoi:10.1089/hum.1998.9.8-1209en_US
dc.identifier.sourceHuman Gene Therapyen_US
dc.identifier.sourceHuman Gene Therapyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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