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End-to-End Anastomosis between Tissue-Engineered Intestine and Native Small Bowel

dc.contributor.authorKaihara, Satoshien_US
dc.contributor.authorKim, Stephenen_US
dc.contributor.authorBenvenuto, Mark S.en_US
dc.contributor.authorKim, Byung-Sooen_US
dc.contributor.authorMooney, David J.en_US
dc.contributor.authorTanaka, Koichien_US
dc.contributor.authorVacanti, Joseph P.en_US
dc.date.accessioned2009-07-10T19:10:20Z
dc.date.available2009-07-10T19:10:20Z
dc.date.issued1999-08-01en_US
dc.identifier.citationKaihara, Satoshi; Kim, Stephen; Benvenuto, Mark; Kim, Byung-Soo; Mooney, David J.; Tanaka, Koichi; Vacanti, Joseph P. (1999). "End-to-End Anastomosis between Tissue-Engineered Intestine and Native Small Bowel." Tissue Engineering 5(4): 339-346 <http://hdl.handle.net/2027.42/63339>en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/63339
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10477856&dopt=citationen_US
dc.description.abstractThe purpose of this study was to demonstrate the feasibility of end-to-end anastomosis between tissue-engineered intestine and native small bowel and to investigate the effect of this anastomosis on their growth. Microporous biodegradable polymer tubes were created from a fiber mesh of polyglycolic acid sprayed with 5% polylactic acid. Intestinal epithelial organoid units were harvested from neonatal Lewis rats and seeded onto polymers. These constructs were implanted into the omentum of adult Lewis rats. Three weeks after the implantation, the constructs (n = 7) were anastomosed to the native jejunum in an end-to-end fashion. Ten weeks after implantation, the tissue-engineered intestine was harvested. Four of 7 rats survived for 10 weeks and the overall patency rate of the anastomosis was 78% (11 of 14 anastomosis). The maximal length of the tissue-engineered intestine at week 3 and 10 was 1.80 ± 0.32 and 1.93 ± 0.39 cm (mean ± SD). Histologically, the tissue-engineered intestine was lined with a well-developed neomucosal layer that was continuous with the native intestine. We conclude that anastomosis between tissue-engineered intestine and native small bowel had a moderately high patency rate and had a positive effect on maintenance of the size of the neointestine and development of the neomucosa.en_US
dc.format.extent2064956 bytes
dc.format.extent2489 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherMary Ann Liebert, Inc., publishersen_US
dc.titleEnd-to-End Anastomosis between Tissue-Engineered Intestine and Native Small Bowelen_US
dc.typeArticleen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.identifier.pmid10477856en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/63339/1/ten.1999.5.339.pdf
dc.identifier.doidoi:10.1089/ten.1999.5.339en_US
dc.identifier.sourceTissue Engineeringen_US
dc.identifier.sourceTissue Engineeringen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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