HIV-1 Infection Increases the Expression of Human Endogenous Retroviruses Type K (HERV-K) in Vitro
dc.contributor.author | Contreras-Galindo, Rafael | en_US |
dc.contributor.author | López, Pablo | en_US |
dc.contributor.author | Vélez, Rosa | en_US |
dc.contributor.author | Yamamura, Yasuhiro | en_US |
dc.date.accessioned | 2009-07-10T19:10:30Z | |
dc.date.available | 2009-07-10T19:10:30Z | |
dc.date.issued | 2007-01-01 | en_US |
dc.identifier.citation | Contreras-Galindo, Rafael; López, Pablo; Vélez, Rosa; Yamamura, Yasuhiro (2007). "HIV-1 Infection Increases the Expression of Human Endogenous Retroviruses Type K (HERV-K) in Vitro." AIDS Research and Human Retroviruses 23(1): 116-122 <http://hdl.handle.net/2027.42/63342> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/63342 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17263641&dopt=citation | en_US |
dc.description.abstract | Antibodies to HERV-K antigens have been linked to HIV-1 infection and expression of HERV-K proteins generates T-cell cytotoxic responses in many cancers. HERV-K RNA and protein abundance was measured in HIV-1-infected and control cells. In vitro exposure of HIV-1 laboratory-adapted and primary isolates on U87MG cells increased the expression of HERV-K RNA in a dose-dependent manner. HERV-K RNA and protein burdens were significantly increased in HIV-1-producing H9 cell lines compared to H9 cells. The expression of HERV-K was synergistically increased in HIV-1-infected PBMCs after stimulation with PMA/ionomycin. Furthermore, the expression of HERV-K in PBMCs, and particularly in CD4+ T cells, was higher in HIV-1 patients compared to control subjects. The expression of HERV-K might be related to HIV-1 pathogenesis and AIDS-associated cancers. | en_US |
dc.format.extent | 353291 bytes | |
dc.format.extent | 2489 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Mary Ann Liebert, Inc., publishers | en_US |
dc.title | HIV-1 Infection Increases the Expression of Human Endogenous Retroviruses Type K (HERV-K) in Vitro | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.identifier.pmid | 17263641 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/63342/1/aid.2006.0117.pdf | |
dc.identifier.doi | doi:10.1089/aid.2006.0117 | en_US |
dc.identifier.source | AIDS Research and Human Retroviruses | en_US |
dc.identifier.source | AIDS Research and Human Retroviruses | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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