Expression of Retroviral Transduced Human CD18 in Murine Cells: An In Vitro Model of Gene Therapy for Leukocyte Adhesion Deficiency

Abstract

Overview summary In developing human gene therapy clinical protocols, it is helpful to have an animal model that mimics the human disease to be treated. A natural animal model for leukocyte adhesion deficiency (LAD) does not exist. Krauss et al. have developed a clever strategy for producing a mouse model for LAD gene therapy.