Transcription factor GATA-3 is essential for lens development
dc.contributor.author | Maeda, Atsuko | en_US |
dc.contributor.author | Moriguchi, Takashi | en_US |
dc.contributor.author | Hamada, Michito | en_US |
dc.contributor.author | Kusakabe, Manabu | en_US |
dc.contributor.author | Fujioka, Yuki | en_US |
dc.contributor.author | Nakano, Takako | en_US |
dc.contributor.author | Yoh, Keigyou | en_US |
dc.contributor.author | Lim, Kim-Chew | en_US |
dc.contributor.author | Engel, James Douglas | en_US |
dc.contributor.author | Takahashi, Satoru | en_US |
dc.date.accessioned | 2009-09-02T14:37:42Z | |
dc.date.available | 2010-10-05T18:27:29Z | en_US |
dc.date.issued | 2009-09 | en_US |
dc.identifier.citation | Maeda, Atsuko; Moriguchi, Takashi; Hamada, Michito; Kusakabe, Manabu; Fujioka, Yuki; Nakano, Takako; Yoh, Keigyou; Lim, Kim-Chew; Engel, James Douglas; Takahashi, Satoru (2009). "Transcription factor GATA-3 is essential for lens development." Developmental Dynamics 238(9): 2280-2291. <http://hdl.handle.net/2027.42/63591> | en_US |
dc.identifier.issn | 1058-8388 | en_US |
dc.identifier.issn | 1097-0177 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/63591 | |
dc.description.abstract | During vertebrate lens development, the anterior, ectoderm-derived lens vesicle cells differentiate into a monolayer of epithelial cells that retain proliferative potential. Subsequently, they exit the cell cycle and give rise to posterior lens fiber cells that form the lens body. In the present study, we demonstrate that the transcription factor GATA-3 is expressed in the posterior lens fiber cells during embryogenesis, and that GATA-3 deficiency impairs lens development. Interestingly, expression of E-cadherin, a premature lens vesicle marker, is abnormally prolonged in the posterior region of Gata3 homozygous mutant lenses. Furthermore, expression of Γ-crystallin, a differentiation marker for fiber cells, is reduced. This suppressed differentiation is accompanied by an abnormal cellular proliferation, as well as with diminished levels of the cell-cycle inhibitors Cdkn1b/p27 and Cdkn1c/p57 and increased Ccnd2/cyclin D2 abundance. Thus, these observations suggest that GATA-3 is essential for lens cells differentiation and proper cell cycle control. Developmental Dynamics 238:2280–2291, 2009. © 2009 Wiley-Liss, Inc. | en_US |
dc.format.extent | 7131443 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley-Liss, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | Transcription factor GATA-3 is essential for lens development | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan | en_US |
dc.contributor.affiliationother | Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan ; Tohoku University Graduate School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan | en_US |
dc.contributor.affiliationother | Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan ; Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Japan | en_US |
dc.contributor.affiliationother | Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan | en_US |
dc.contributor.affiliationother | Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan | en_US |
dc.contributor.affiliationother | Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan | en_US |
dc.contributor.affiliationother | Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan | en_US |
dc.contributor.affiliationother | Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan ; Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Japan | en_US |
dc.identifier.pmid | 19623612 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/63591/1/22035_ftp.pdf | |
dc.identifier.doi | 10.1002/dvdy.22035 | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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