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| Title: | Race/ethnicity and telomere length in the Multi-Ethnic Study of Atherosclerosis |
| Authors: | Diez Roux, Ana
Ranjit, Nalini
Jenny, Nancy
Shea, Steven
Cushman, Mary
Fitzpatric, Annette
Seeman, Teresa |
| Keywords: | aging
race/ethnicity
telomeres |
| Issue Date: | 16-Feb-2009 |
| Abstract: | Telomere length has emerged as a marker of exposure to oxidative stress and aging. Race ⁄ ethnic differences in telomere length have been infrequently investigated.
Leukocyte telomere length (LTL) was assessed 981 white, black and Hispanic men and women aged 45–84 years participating in the Multi-Ethnic Study of Atherosclerosis. Direct measurement and questionnaire were used to assess covariates. Linear regression was
used to estimate associations of LTL with race ⁄ ethnicity and age after adjustment for sex, income, education, smoking, physical activity, diet and body mass index.
On average blacks and Hispanics had shorter telomeres than whites [adjusted mean differences (standard error)in T ⁄ S ratio compared to whites: )0.041 (0.018) for
blacks and )0.044 (0.018) for Hispanics]. Blacks and Hispanics showed greater differences in telomere length associated with age than whites (adjusted mean differences in T ⁄ S ratio per 1 year increase in age )0.0018,)0.0047 and )0.0055 in whites, blacks and Hispanics respectively). Differences in age associations were more pronounced and only statistically significant in women.
Race ⁄ ethnic differences in LTL may reflect the cumulative burden of differential exposure to oxidative stress
(and its predictors) over the lifecourse.
Key words: aging; race ⁄ ethnicity; telomeres. |
| DOI: | 10.1111/j.1474-9726.2009.00470.x |
| Appears in Collections: | Interdisciplinary and Peer-Reviewed
Epidemiology, Department of (SPH)
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Files in This Item:
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Size | Format | |
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| race_ethnicity_telomerelength_agingcell.pdf | Main article | 137Kb | Adobe PDF | View/Open |
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