A Restrictive Inflow Pattern Does Not Predict Implantable Cardioverter-Defibrillator Therapy in Primary Prevention
dc.contributor.author | Dorosz, Jennifer L. | en_US |
dc.contributor.author | Aaronson, Keith D. | en_US |
dc.contributor.author | Good, Eric D. | en_US |
dc.contributor.author | Kolias, Theodore J. | en_US |
dc.date.accessioned | 2010-01-05T15:10:06Z | |
dc.date.available | 2010-03-01T21:10:28Z | en_US |
dc.date.issued | 2009-12 | en_US |
dc.identifier.citation | Dorosz, Jennifer L.; Aaronson, Keith D.; Good, Eric D.; Kolias, Theodore J. (2009). "A Restrictive Inflow Pattern Does Not Predict Implantable Cardioverter-Defibrillator Therapy in Primary Prevention." Clinical Cardiology 32(12): E32-E35. <http://hdl.handle.net/2027.42/64537> | en_US |
dc.identifier.issn | 0160-9289 | en_US |
dc.identifier.issn | 1932-8737 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/64537 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=20014210&dopt=citation | en_US |
dc.description.abstract | Background Current guidelines for the use of implantable cardioverter-defibrillators (ICDs) are broad and significantly increase the cost of caring for patients with heart failure. In an effort to identify the specific subset of patients who benefit from this therapy, the predictive value of numerous echocardiographic parameters have been studied. Severe diastolic dysfunction has been shown to predict adverse events in a group of patients who received an ICD for secondary prevention, but has not been tested in those who receive ICDs for primary prevention. Hypothesis We tested the hypothesis that a restrictive mitral inflow pattern on echocardiography will predict the risk of appropriate therapy in this patient population. Methods This retrospective study identified 145 consecutive patients who met primary prevention criteria for ICD implantation and had an echo performed no more than 1 year prior to receiving the ICD. A restrictive pattern was defined as a mitral inflow E/A > 2 or a deceleration time < 150 ms. Results A restrictive pattern was present in 69 patients (40.7% of the group). Appropriate ICD therapy occurred in 8 (11.5%) subjects with a restrictive pattern and 14 (18.4%) with a nonrestrictive pattern over 680 days of average follow-up ( P = not significant). Cox regression analysis showed the presence of a restrictive pattern was not helpful in predicting time to first ICD therapy. Conclusions In a population of patients who received ICDs for primary prevention, echocardiographic findings of severe diastolic dysfunction were not helpful in targeting the use of ICDs to those at highest risk. Copyright © 2009 Wiley Periodicals, Inc. | en_US |
dc.format.extent | 93277 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Periodicals, Inc. | en_US |
dc.subject.other | Medicine and Healthcare | en_US |
dc.subject.other | Cardiovascular Disease | en_US |
dc.title | A Restrictive Inflow Pattern Does Not Predict Implantable Cardioverter-Defibrillator Therapy in Primary Prevention | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialities | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, Michigan ; University of Colorado Cardiac & Vascular Center 12606 E. 16th Ave, Mail Stop B120 PO Box 6510 Aurora, CO 80045 | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, Michigan | en_US |
dc.identifier.pmid | 20014210 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/64537/1/20474_ftp.pdf | |
dc.identifier.doi | 10.1002/clc.20474 | en_US |
dc.identifier.source | Clinical Cardiology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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