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Role of bone morphogenetic proteins on cochlear hair cell formation: Analyses of Noggin and Bmp2 mutant mice

dc.contributor.authorHwang, Chan Hoen_US
dc.contributor.authorGuo, Dayongen_US
dc.contributor.authorHarris, Marie A.en_US
dc.contributor.authorHoward, Omaren_US
dc.contributor.authorMishina, Yujien_US
dc.contributor.authorGan, Linen_US
dc.contributor.authorHarris, Stephen E.en_US
dc.contributor.authorWu, Doris K.en_US
dc.date.accessioned2010-02-02T15:31:34Z
dc.date.available2011-03-01T16:26:44Zen_US
dc.date.issued2010-02en_US
dc.identifier.citationHwang, Chan Ho; Guo, Dayong; Harris, Marie A.; Howard, Omar; Mishina, Yuji; Gan, Lin; Harris, Stephen E.; Wu, Doris K. (2010). "Role of bone morphogenetic proteins on cochlear hair cell formation: Analyses of Noggin and Bmp2 mutant mice." Developmental Dynamics 239(2): 505-513. <http://hdl.handle.net/2027.42/64918>en_US
dc.identifier.issn1058-8388en_US
dc.identifier.issn1097-0177en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/64918
dc.description.abstractThe mammalian organ of Corti of the inner ear is a highly sophisticated sensory end organ responsible for detecting sound. Noggin is a secreted glycoprotein, which antagonizes bone morphogenetic proteins 2 and 4 (Bmp2 and Bmp4). The lack of this antagonist causes increased rows of inner and outer hair cells in the organ of Corti. In mice, Bmp2 is expressed transiently in nascent cochlear hair cells. To investigate whether Noggin normally modulates the levels of Bmp2 for hair cell formation, we deleted Bmp2 in the cochlear hair cells using two cre strains, Foxg1 cre /+ and Gfi1 cre /+ . Bmp2 conditional knockout cochleae generated using these two cre strains show normal hair cells. Furthermore, Gfi1 cre /+ ; Bmp2 lox /− mice are viable and have largely normal hearing. The combined results of Noggin and Bmp2 mutants suggest that Noggin is likely to regulate other Bmps in the cochlea such as Bmp4. Developmental Dynamics 239:505–513, 2010. Published 2010 Wiley-Liss, Inc.en_US
dc.format.extent561589 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley-Liss, Inc.en_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCell & Developmental Biologyen_US
dc.titleRole of bone morphogenetic proteins on cochlear hair cell formation: Analyses of Noggin and Bmp2 mutant miceen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPediatricsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationotherLaboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, Rockville, Marylanden_US
dc.contributor.affiliationotherDepartment of Periodontics and Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texasen_US
dc.contributor.affiliationotherDepartment of Periodontics and Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texasen_US
dc.contributor.affiliationotherLaboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, Rockville, Marylanden_US
dc.contributor.affiliationotherUniversity of Rochester Eye Institute, University of Rochester, Rochester, New Yorken_US
dc.contributor.affiliationotherDepartment of Periodontics and Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texasen_US
dc.contributor.affiliationotherLaboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, Rockville, Maryland ; Laboratory of Molecular Biology, NIDCD/NIH, 5 Research Court, Rm 2B34, Rockville, MD 20850en_US
dc.identifier.pmid20063299en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/64918/1/22200_ftp.pdf
dc.identifier.doi10.1002/dvdy.22200en_US
dc.identifier.sourceDevelopmental Dynamicsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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