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Is Hyperglycemia Associated with Frailty Status in Older Women?
dc.contributor.authorBlaum, Caroline S.en_US
dc.contributor.authorXue, Qian Lien_US
dc.contributor.authorTian, Jingen_US
dc.contributor.authorSemba, Richard D.en_US
dc.contributor.authorFried, Linda P.en_US
dc.contributor.authorWalston, Jeremyen_US
dc.date.accessioned2010-04-01T14:49:18Z
dc.date.available2010-04-01T14:49:18Z
dc.date.issued2009-05en_US
dc.identifier.citationBlaum, Caroline S.; Xue, Qian Li; Tian, Jing; Semba, Richard D.; Fried, Linda P.; Walston, Jeremy (2009). "Is Hyperglycemia Associated with Frailty Status in Older Women?." Journal of the American Geriatrics Society 57(5): 840-847. <http://hdl.handle.net/2027.42/65272>en_US
dc.identifier.issn0002-8614en_US
dc.identifier.issn1532-5415en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/65272
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=19484839&dopt=citationen_US
dc.description.abstractTo determine whether hyperglycemia is related to prevalent frailty status in older women. DESIGN : Secondary data analysis of baseline data of a prospective cohort study. SETTING : Baltimore, Maryland. PARTICIPANTS : Five hundred forty-three women aged 70 to 79. METHODS : Research used baseline data from 543 participants in the Women's Health and Aging Studies I and II aged 70 to 79 who had all variables needed for analyses. The dependent variable was baseline frailty status (not frail, prefrail, frail), measured using an empirically derived model defining frailty according to weight loss, slow walking speed, weakness, exhaustion, and low activity (1–2 characteristics present=prefrail, ≥3=frail). Covariates included body mass index (BMI), interleukin-6 (IL-6), age, race, and several chronic diseases. Analyses included descriptive methods and multinomial logistic regression to adjust for key covariates. RESULTS : A hemoglobin A1c (HbA1c) level of 6.5% or greater in older women was significantly associated with higher likelihood of prefrail and frail status (normal HbA1c <6.0% was reference). The association between HbA1C levels of 6.0% to 6.5% and frailty status was not different from that of normal HbA1c, but HbA1c levels of 6.5% to 6.9% had nearly twice the likelihood of frailty (odds ratio (OR)=1.96, 95% confidence interval (CI)=1.47–2.59) as normal HbA1c. A HbA1c level of 9.0% or greater was also strongly associated (OR=2.57, 95% CI=1.99,3.32). Significant associations were also seen between baseline prefrail and frail status and low (18.5–20.0 kg/m 2 ) and high (>30.0 kg/m 2 ) body mass index (BMI), interleukin-6, and all chronic diseases evaluated, but controlling for these covariates only minimally attenuated the independent association between HbA1c and frailty status. CONCLUSION : Hyperglycemia is associated with greater prevalence of prefrail and frail status; BMI, inflammation, and comorbidities do not explain the association. Longitudinal research and study of alternative pathways are needed.en_US
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dc.format.extent3110 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Publishing Incen_US
dc.rightsJournal compilation 2009 The American Geriatrics Society/Wiley Periodicals, Inc.en_US
dc.subject.otherHyperglycemiaen_US
dc.subject.otherFrailtyen_US
dc.subject.otherOlder Womenen_US
dc.titleIs Hyperglycemia Associated with Frailty Status in Older Women?en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelGeriatricsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDivision of Geriatric Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan ;en_US
dc.contributor.affiliationumGeriatric Research, Education and Clinical Center, Veterans Administration Health Center, Ann Arbor, Michigan ;en_US
dc.contributor.affiliationotherDivision of Geriatric Medicine and Gerontology, Department of Medicine ,en_US
dc.contributor.affiliationotherCenter on Aging and Health, anden_US
dc.contributor.affiliationotherDepartment of Ophthalmology, The Johns Hopkins Medical Institutions, Baltimore, Maryland ;en_US
dc.contributor.affiliationotherDepartment of Public Health, Mailman School of Public Health, anden_US
dc.contributor.affiliationotherDepartment of Epidemiology and Medicine, Columbia University Medical Center, Columbia University, New York, New York.en_US
dc.identifier.pmid19484839en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/65272/1/j.1532-5415.2009.02196.x.pdf
dc.identifier.doi10.1111/j.1532-5415.2009.02196.xen_US
dc.identifier.sourceJournal of the American Geriatrics Societyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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