Dementia of the Alzheimer's Type: Changes in Hippocampal L-[ 3 H]Glutamate Binding
dc.contributor.author | Greenamyre, J. Timothy | en_US |
dc.contributor.author | Penney, John B. | en_US |
dc.contributor.author | D'Amato, Constance J. | en_US |
dc.contributor.author | Young, Anne B. | en_US |
dc.date.accessioned | 2010-04-01T14:51:47Z | |
dc.date.available | 2010-04-01T14:51:47Z | |
dc.date.issued | 1987-02 | en_US |
dc.identifier.citation | Greenamyre, J. Timothy; Penney, John B.; D'Amato, Constance J.; Young, Anne B. (1987). "Dementia of the Alzheimer's Type: Changes in Hippocampal L-[ 3 H]Glutamate Binding." Journal of Neurochemistry 48(2): 543-551. <http://hdl.handle.net/2027.42/65316> | en_US |
dc.identifier.issn | 0022-3042 | en_US |
dc.identifier.issn | 1471-4159 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/65316 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2878980&dopt=citation | en_US |
dc.description.abstract | Glutamate or a related excitatory amino acid is thought to be the major excitatory neurotransmitter of hippocampal afferents, intrinsic neurons, and efferents. We have used an autoradiographic technique to investigate the status of excitatory amino acid receptors in the hippocampal formation of patients dying with dementia of the Alzheimer type (DAT). We examined l-[ 3 H]glutamate binding to sections from the hippocampal formation of six patients dying of DAT and six patients without DAT and found marked reductions in total [ 3 H]glutamate binding in all regions of hippocampus and adjacent parahippocampal cortex in DAT brains as compared to controls. When subtypes of excitatory amino acid receptors were assayed, it was found that binding to the N -methyl-d-aspartate (NMDA)-sensitive receptor was reduced by 75–87%, with the greatest loss found in stratum moleculare and stratum pyramidale of CA1. Binding to quisqualate (QA)-sensitive receptors was reduced by 45–69%. There were smaller reductions (21–46%) in GABA A receptors in DAT cases. Muscarinic cholinergic receptors assayed in adjacent sections of hippocampal formation were unchanged in DAT. Benzodiazepine receptors were reduced significantly only in parahippocampal cortex by 44%. These results suggest that glutamatergic neurotransmission within the hippocampal formation is likely to be severely impaired in Alzheimer's disease. Such impairment may account for some of the cognitive decline and memory deficits that characterize DAT. | en_US |
dc.format.extent | 2269026 bytes | |
dc.format.extent | 3110 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 1987 International Society for Neurochemistry | en_US |
dc.subject.other | Alzheimer's Disease | en_US |
dc.subject.other | Glutamate | en_US |
dc.subject.other | N -Methyl-d-Aspartate | en_US |
dc.subject.other | Quisqualate | en_US |
dc.subject.other | Excitotoxins | en_US |
dc.title | Dementia of the Alzheimer's Type: Changes in Hippocampal L-[ 3 H]Glutamate Binding | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Neuroscience Program and Departments of Neurology, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | * Neuroscience Program and Departments of Pathology, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.identifier.pmid | 2878980 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/65316/1/j.1471-4159.1987.tb04127.x.pdf | |
dc.identifier.doi | 10.1111/j.1471-4159.1987.tb04127.x | en_US |
dc.identifier.source | Journal of Neurochemistry | en_US |
dc.identifier.citedreference | Alzheimer A. ( 1907 ) Ubereine eigenartige Erkrankung der Hirnrinde. Allg. Z. Psychiatr. 64, 146 – 148. | en_US |
dc.identifier.citedreference | Antuono P. G., Lehman J., Roller K. J., Whitehouse P. J., Clark A. M., Struble R. G., Price D. L., and Coyle J. T. ( 1984 ) Endogenous neurotransmitter amino acids (ENAA) in Alzheimer's disease (AD). Neurology 34 ( Suppl 1 ), 119. | en_US |
dc.identifier.citedreference | Arai H., Kobayashi H. K., Ichima Y., Kosaka K., and Iizuka R. ( 1985 ) A preliminary study of free amino acids in the post mortem temporal cortex from Alzheimer type dementia patients. Neurobiol. Aging 5, 319 – 322. | en_US |
dc.identifier.citedreference | Baughman R. W. and Gilbert C. D. ( 1981 ) Aspartate and glutamate as possible neurotransmitters in the visual cortex. J Neurosci. 1, 427 – 439. | en_US |
dc.identifier.citedreference | Clark R. M. and Collins G. G. S. ( 1976 ) The release of endogenous amino acids from rat visual cortex. J. Physiol. (Lond.) 262, 383 – 400. | en_US |
dc.identifier.citedreference | Coan E. S. and Collingridge G. L. ( 1985 ) Magnesium ions block an N-methyl-d-aspartate receptor-mediated component of synaptic transmission in rat hippocampus. Neurosci. Lett. 53, 21 – 26. | en_US |
dc.identifier.citedreference | Collingridge G. L. ( 1985 ) Long term potentiation in the hippocampus: mechanisms of initiation and modulation by neurotransmitters. Trends Pharmacol. Sci. 6, 407 – 411. | en_US |
dc.identifier.citedreference | Crunelli V., Forda S., Collingridge G. L., and Kelley J. S. ( 1982 ) Intracellular recorded synaptic antagonism in the rat dentate gyrus. Nature 300, 450 – 452. | en_US |
dc.identifier.citedreference | Dauth G. W., Frey K. A., and Gilman S. ( 1984 ) A densitometer for quantitative autoradiography. J. Neurosci. Methods 9, 243 – 251. | en_US |
dc.identifier.citedreference | Esiri M. M., Pearson R. C. A., and Powell T. P. S. ( 1986 ) The cortex of the primary auditory area in Alzheimer's disease. Brain Res. 366, 385 – 387. | en_US |
dc.identifier.citedreference | Fonnum F., Soreide A., Kvale I., Walker J., and Walaas I. ( 1981 ) Glutamate in cortical fibers. Adv. Biochem. Psychopharmacol. 27, 29 – 41. | en_US |
dc.identifier.citedreference | Geddes J. W., Monaghan D. T., Lott I. T., Kim R. C., and Chui H. C. ( 1985 ) Plasticity of hippocampal circuitry in Alzheimer's disease. Science 230, 1179 – 1181. | en_US |
dc.identifier.citedreference | Greenamyre J. T., Young A. B., and Penney J. B. ( 1984 ) Quantitative autoradiographic distribution of l-[ 3 H]glutamate-binding sites in rat central nervous system. J. Neurosci. 4, 2133 – 2144. | en_US |
dc.identifier.citedreference | Greenamyre J. T., Olson J. M. M., Penney J. B., and Young A. B. ( 1985a ) Autoradiographic characterization of N-methyl-d-aspartate-, quisqualate- and kainate-sensitive glutamate binding sites. J. Pharmacol. Exp. Ther. 233, 254 – 263. | en_US |
dc.identifier.citedreference | Greenamyre J. T., Penney J. B., Young A. B., D'Amato C. J., Hicks S. P., and Shoulson I. ( 1985b ) Alterations in l-glutamate binding in Alzheimer's and Huntington's diseases. Science 227, 1496 – 1499. | en_US |
dc.identifier.citedreference | Halpain S. H., Wieczorek C. M., and Rainbow T. C. ( 1984 ) Localization of l-glutamate receptors in rat brain by quantitative autoradiography. J. Neurosci. 4, 2247 – 2258. | en_US |
dc.identifier.citedreference | Hicks T. P. and Geddes R. C. A. ( 1981 ) Synaptic transmission in suprasylvian visual cortex is reduced by excitatory amino acid antagonists. Can. J. Physiol. Pharmacol. 59, 893 – 896. | en_US |
dc.identifier.citedreference | Hjorth-Simonsen A. ( 1973 ) Some intrinsic connections of the hippocampus in the rat: an experimental analysis. J. Comp. Neurol. 147, 145 – 162. | en_US |
dc.identifier.citedreference | Horel J. A. ( 1978 ) The neuroanatomy of amnesia: a critique of the hippocampal memory hypothesis. Brain 101, 403 – 445. | en_US |
dc.identifier.citedreference | Hyman B. T., Van Hoesen G. W., Damasio A. R., and Barns C. L. ( 1984 ) Alzheimer's disease: cell-specific pathology isolates the hippocampal formation. Science 225, 1168 – 1170. | en_US |
dc.identifier.citedreference | Hyman B. T., Van Hoesen G. W., and Damasio A. R. ( 1986 ) Glutamate depletion of the perforant pathway terminal zone in Alzheimer's disease. Soc. Neurosci. Abstr. 12, 994. | en_US |
dc.identifier.citedreference | Khachaturian Z. S. ( 1985 ) Diagnosis of Alzheimer's disease. Arch. Neurol. 42, 1097 – 1105. | en_US |
dc.identifier.citedreference | Lorente de No R. ( 1934 ) Studies on the structure of the cerebral cortex II. Continuation of the study of the ammonic system. J. Psychol. Neurol. 46, 113 – 177. | en_US |
dc.identifier.citedreference | Mann D. M. A., Yates P. O., and Marcyniuk B. ( 1986 ) A comparison of nerve cell loss in cortical and subcortical structures in Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry 49, 310 – 312. | en_US |
dc.identifier.citedreference | Maragos W. F., Debowey D. L., Reiner A., Rustioni A., Penney J. B., and Young A. B. ( 1986 ) Co-localization of Congo redstained neurofibrillary tangles in glutamate immunoreactive neurons in hippocampus. Soc. Neurosci. Abstr. 12, 242. | en_US |
dc.identifier.citedreference | McKhann G., Drachman D., Folstein M., Katzman R., Price D., and Stadlan E. M. ( 1984 ) Clinical diagnosis of Alzheimer's disease. Neurology 34, 939 – 944. | en_US |
dc.identifier.citedreference | Mehraein P., Yamada M., and Tarnowska-Dziduszko E. ( 1975 ) Quantitative study on dendrites and dendritic spines in Alzheimer's disease and senile dementia. Adv. Neurol. 12, 453 – 458. | en_US |
dc.identifier.citedreference | Monaghan D. T., Holets V. R., Toy D. W., and Cotman C. W. ( 1983 ) Anatomical distribution of four pharmacologically distinct 3 H-l-glutamate binding sites. Nature 306, 176 – 179. | en_US |
dc.identifier.citedreference | Morris R. G. M., Anderson E., Lynch G., and Baudry M. ( 1986 ) Selective impairment of learning and blockade of long term potentiation by an N-methyl-d-aspartate receptor antagonist, AP-5. Nature 319, 774 – 776. | en_US |
dc.identifier.citedreference | Munson P. J. and Rodbard D. ( 1980 ) Ligand: a versatile computerized approach for characterization of ligand-binding systems. Anal. Biochem. 107, 220 – 239. | en_US |
dc.identifier.citedreference | Olson J. M. M., Greenamyre J. T., Penney J. B., and Young A. B. ( 1985 ) Autoradiographic localization of cerebellar glutamate receptor subtypes. Soc. Neurosci. Abstr. 11, 110. | en_US |
dc.identifier.citedreference | Pan H. S., Frey K. A., Young A. B., and Penney J. B. ( 1983 ) Changes in [ 3 H]muscimol binding in substantia nigra, entopeduncular nucleus, globus pallidus and thalamus after striatal lesions as demonstrated by quantitative autoradiography. J. Neurosci. 3, 1189 – 1198. | en_US |
dc.identifier.citedreference | Pan H. S., Penney J. B., and Young A. B. ( 1984 ) Characterization of benzodiazepine receptor changes in substantia nigra, globus pallidus and entopeduncular nucleus after striatal lesions. J. Pharmacol. Exp. Ther. 230, 768 – 775. | en_US |
dc.identifier.citedreference | Pearson R. C. A., Esiri M. M., Hiorns R. W., Wilcock G. K., and Powell T. P. S. ( 1985 ) Anatomical correlates of the pathological changes in the neocortex in Alzheimer's disease. Proc. Natl. Acad. Sci. USA 82, 4531 – 4534. | en_US |
dc.identifier.citedreference | Penney J. B. and Young A. B. ( 1982 ) Quantitative autoradiography of neurotransmitter receptors in Huntington's disease. Neurology 32, 1391 – 1395. | en_US |
dc.identifier.citedreference | Penney J. B. and Young A. B. ( 1984 ) Quantitative autoradiography of neurotransmitter receptors in Alzheimer's disease. Neurology 34 ( Suppl 1 ), 150. | en_US |
dc.identifier.citedreference | Perry E. K., Atack J. R., Perry R. H., Hardy J. A., Dodd P. R., Edwardson J. A., Blessed G., Tomlinson B. E., and Fairbairn A. F. ( 1984 ) Intralaminar neurochemical distributions in human midtemporal cortex: comparison between Alzheimer's disease and the normal. J. Neurochem. 42, 1402 – 1410. | en_US |
dc.identifier.citedreference | Rogers J. and Morrison J. H. ( 1985 ) Quantitative morphology and regional laminar distributions of senile plaques in Alzheimer's disease. J. Neurosci. 5, 2801 – 2808. | en_US |
dc.identifier.citedreference | Smith C. C. T., Bowen D. M., Francis P. T., Snowden J. S., and Neary D. ( 1985 ) Putative amino acid transmitters in lumbar cerebrospinal fluid of patients with histologically verified Alzheimer's dementia. J. Neurol. Neurosurg. Psychiatry 48, 469 – 471. | en_US |
dc.identifier.citedreference | Storm-Mathisen J. ( 1977 ) Glutamic acid and excitatory nerve endings: reductions of glutamic acid uptake after axotomy. Brain Res. 120, 379 – 386. | en_US |
dc.identifier.citedreference | Storm-Mathisen J. ( 1981 ) Glutamate in hippocampal pathways. Adv. Biochem. Psychopharmacol. 27, 43 – 55. | en_US |
dc.identifier.citedreference | Swanson L. W., Wyss J. M., and Cowan W. M. ( 1978 ) An autoradiographic study of the organization of intrahippocampal association pathways in the rat. J. Comp. Neurol. 181, 681 – 716. | en_US |
dc.identifier.citedreference | Terry R. D. and Katzman R. ( 1983 ) Senile dementia of the Alzheimer type: defining a disease, in The Neurology of Aging ( Katzman R. and Terry R. D., eds ), pp. 51 – 84. F. A. Davis, New York. | en_US |
dc.identifier.citedreference | Thomson A. M., West D. C., and Lodge D. ( 1985 ) An N-methylaspartate receptor-mediated synapse in rat cerebral cortex: a site of action of ketamine ? Nature 313, 479 – 481. | en_US |
dc.identifier.citedreference | Van Hoesen G. W. and Pandya D. P. ( 1975 ) Some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesis monkey. III. Efferent connections. Brain Res. 95, 39 – 59. | en_US |
dc.identifier.citedreference | Victor M., Angevine J. B., Mancall E. L., and Fisher C. M. ( 1961 ) Memory loss with lesions of the hippocampal formation. Arch. Neurol. 5, 244 – 263. | en_US |
dc.identifier.citedreference | Walker F. O., Young A. B., Penney J. B., Dorovini-Zis K., and Shoulson I. ( 1984 ) Benzodiazepine and GABA receptors in early Huntington's disease. Neurology 34, 1237 – 1240. | en_US |
dc.identifier.citedreference | Watkins J. C. and Evans R. H. ( 1981 ) Excitatory amino acid neurotransmitters. Annu. Rev. Pharmacol. Toxicol. 21, 165 – 204. | en_US |
dc.identifier.citedreference | White W. F., Nadler J. V., Hamberger A., Cotman C. W., and Cummins J. T. ( 1977 ) Glutamate as a transmitter of the hippocampal perforant path. Nature 270, 356 – 357. | en_US |
dc.identifier.citedreference | Wurtman R. J., Corkin S. H., Growdon J. H., eds ( 1984 ) Alzheimer's disease; Advances in Basic Research and Therapies. Center for Brain Sciences and Metabolism Charitable Trust, Cambridge, Massachusetts. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.