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Insulin-like growth factor-I and Bcl-X L inhibit c-jun N-terminal kinase activation and rescue Schwann cells from apoptosis

dc.contributor.authorCheng, Hsin-Linen_US
dc.contributor.authorSteinway, Matthew L.en_US
dc.contributor.authorXin, Xipingen_US
dc.contributor.authorFeldman, Eva L.en_US
dc.date.accessioned2010-04-01T14:53:01Z
dc.date.available2010-04-01T14:53:01Z
dc.date.issued2001-02en_US
dc.identifier.citationCheng, Hsin-Lin; Steinway, Matthew L.; Xin, Xiping; Feldman, Eva L. (2001). "Insulin-like growth factor-I and Bcl-X L inhibit c-jun N-terminal kinase activation and rescue Schwann cells from apoptosis." Journal of Neurochemistry 76(3): 935-943. <http://hdl.handle.net/2027.42/65337>en_US
dc.identifier.issn0022-3042en_US
dc.identifier.issn1471-4159en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/65337
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11158266&dopt=citationen_US
dc.format.extent436311 bytes
dc.format.extent3110 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Science Ltden_US
dc.rightsInternational Society for Neurochemistryen_US
dc.subject.otherApoptosisen_US
dc.subject.otherBcl-X Len_US
dc.subject.otherCaspaseen_US
dc.subject.otherC-jun N-terminal Protein Kinaseen_US
dc.subject.otherInsulin-like Growth Factor-Ien_US
dc.subject.otherSchwann Cellsen_US
dc.titleInsulin-like growth factor-I and Bcl-X L inhibit c-jun N-terminal kinase activation and rescue Schwann cells from apoptosisen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USAen_US
dc.identifier.pmid11158266en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/65337/1/j.1471-4159.2001.00110.x.pdf
dc.identifier.doi10.1046/j.1471-4159.2001.00110.xen_US
dc.identifier.sourceJournal of Neurochemistryen_US
dc.identifier.citedreferenceAdams J. M. & Cory S. ( 1998 ) The Bcl-2 protein family: arbiters of cell survival. Science 281, 1322 – 1326.en_US
dc.identifier.citedreferenceAmeyar M., Atfi A., Cai Z., Stancou R., Shatrov V., Bettaieb A. & Chouaib S. ( 1998 ) Analysis of human breast adenocarcinoma MCF7 resistance to tumor necrosis factor-induced cell death. Lack of correlation between JNK activation and ceramide pathway. J.  Biol. Chem. 273, 29002 – 29008.en_US
dc.identifier.citedreferenceAssefa Z., Vantieghem A., Declercq W., Vandenabeele P., Vandenheede J. R., Merlevede W., de Witte P. & Agostinis P. ( 1999 ) The activation of the c-June N-terminal kinase and p38 mitogen-activated protein kinase signaling pathways protects HeLa cells from apoptosis following photodynamic therapy with hypericin. J.  Biol. Chem. 274, 8788 – 8796.en_US
dc.identifier.citedreferenceBost F., McKay R., Dean N. & Mercola D. ( 1997 ) The JUN kinase/stress-activated protein kinase pathway is required for epidermal growth factor stimulation of growth of human A549 lung carcinoma cells. J. Biol. Chem. 272, 33422 – 33429.en_US
dc.identifier.citedreferenceBrenner B., Koppenhoefer U., Weinstock C., Linderkamp O., Lang F. & Gulbins E. ( 1997 ) Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of June N-terminal kinase/p38 kinases and GADD153. J. Biol. Chem. 272, 22173 – 22181.en_US
dc.identifier.citedreferenceBrockes J. P., Fields K. L. & Raff M. C. ( 1979 ) Studies on cultured rat Schwann cells. I. Establishment of purified populations from cultures of peripheral nerve. Brain Res. 165, 105 – 118.en_US
dc.identifier.citedreferenceCampana W. M., Darin S. J. & O'brien J. S. ( 1999 ) Phosphatidylinositol 3-kinase and Akt protein kinase mediate IGF-I- and prosaptide-induced survival in Schwann cells. J. Neurosci. Res. 57, 332 – 341.en_US
dc.identifier.citedreferenceChaudhary P. M., Eby M. T., Jasmin A. & Hood L. ( 1999 ) Activation of the c-June N-terminal kinase/stress-activated protein kinase pathway by overexpression of caspase-8 and its homologs. J. Biol. Chem. 274, 19211 – 19219.en_US
dc.identifier.citedreferenceChauhan D., Pandey P., Ogata A., Teoh G., Treon S., Urashima M., Kharbanda S. & Anderson K. C. ( 1997 ) Dexamethasone induces apoptosis of multiple myeloma cells in a JNK/SAP kinase independent mechanism. Oncogene 15, 837 – 843.en_US
dc.identifier.citedreferenceChen Y. R., Wang X., Templeton D., Davis R. J. & Tan T.-H. ( 1996 ) The role of c-jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and γ radiation. J. Biol. Chem. 271, 31929 – 31936.en_US
dc.identifier.citedreferenceChen Y. R., Wang W., Kong A. N. & Tan T. H. ( 1998 ) Molecular mechanisms of c-June N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates. J. Biol. Chem. 273, 1769 – 1775.en_US
dc.identifier.citedreferenceChen Y. R., Zhou G. & Tan T. H. ( 1999 ) c-June N-terminal kinase mediates apoptotic signaling induced by N -(4-hydroxyphenyl) retinamide. Mol. Pharmacol. 56, 1271 – 1279.en_US
dc.identifier.citedreferenceCheng H.-L. & Feldman E. L. ( 1998 ) Bi-directional regulation of p38 kinase and c-June N-terminal protein kinase by insulin-like growth factor-I. J. Biol. Chem. 273, 14560 – 14565.en_US
dc.identifier.citedreferenceDavies A. M. ( 1995 ) The Bcl-2 family of proteins, and the regulation of neuronal survival. Trends Neurosci. 18, 355 – 358.en_US
dc.identifier.citedreferenceDe Cesaris P., Starace D., Starace G., Filippini A., Stefanini M. & Ziparo E. ( 1999 ) Activation of June N-terminal kinase/stress-activated protein kinase pathway by tumor necrosis factor alpha leads to intercellular adhesion molecule-1 expression. J. Biol. Chem. 274, 28978 – 28982.en_US
dc.identifier.citedreferenceDelaney C. L., Cheng H.-L. & Feldman E. L. ( 1999 ) Insulin-like growth factor-I prevents caspase mediated apoptosis in Schwann cells. J. Neurobiol. 41, 540 – 548.en_US
dc.identifier.citedreferenceDerijard B., Hibi M., Wu I.-H., Barrett T., Su B., Deng T., Karin M. & Davis R. J. ( 1994 ) JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-June activation domain. Cell 76, 1025 – 1037.en_US
dc.identifier.citedreferenceDong C., Yang D. D., Wysk M., Whitmarsh A. J., Davis R. J. & Flavell R. A. ( 1998 ) Defective T cell differentiation in the absence of Jnk1. Science 282, 2092 – 2095.en_US
dc.identifier.citedreferenceEilers A., Whitfield J., Babij C., Rubin L. L. & Ham J. ( 1998 ) Role of the June kinase pathway in the regulation of c-June expression and apoptosis in sympathetic neurons. J. Neurosci. 18, 1713 – 1724.en_US
dc.identifier.citedreferenceEvan G. & Littlewood T. ( 1998 ) A matter of life and cell death. Science 281, 1317 – 1322.en_US
dc.identifier.citedreferenceFeldman E. L., Sullivan K. A., Kim B. & Russell J. W. ( 1997 ) Insulin-like growth factors regulate neuronal differentiation and survival. Neurobiol. Dis. 4, 201 – 214.en_US
dc.identifier.citedreferencevan Golen C. M. & Feldman E. L. ( 2000 ) Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J. Cell. Physiol. 182, 24 – 32.en_US
dc.identifier.citedreferencevan Golen C. M., Castle V. P. & Feldman E. L. ( 2000 ) IGF-I receptor activation and Bcl-2 overexpression prevent early apoptotic events in human neuroblastoma. Cell Death Differ. 7, 654 – 665.en_US
dc.identifier.citedreferenceGraves J. D., Draves K. E., Craxton A., Saklatvala J., Krebs E. G. & Clark E. A. ( 1996 ) Involvement of stress-activated protein kinase and p38 mitogen-activated protein kinase in mIgM-induced apoptosis of human B lymphocytes. Proc. Natl Acad. Sci. USA 93, 13814 – 13818.en_US
dc.identifier.citedreferenceGross A., Yin X. M., Wang K., Wei M. C., Jockel J., Milliman C., Erdjument-Bromage H., Tempst P. & Korsmeyer S. J. ( 1999 ) Caspase cleaved BID targets mitochondria and is required for cytochrome  c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J. Biol. Chem. 274, 1156 – 1163.en_US
dc.identifier.citedreferenceGupta S., Barrett T., Whitmarsh A. J., Cavanagh J., Sluss H. K., Derijard B. & Davis R. ( 1996 ) Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J. 15, 2760 – 2770.en_US
dc.identifier.citedreferenceGupta K., Kshirsagar S., Li W., Gui L., Ramakrishnan S., Gupta P., Law   P. Y. & Hebbel R. P. ( 1999 ) VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signaling. Exp. Cell Res. 247, 495 – 504.en_US
dc.identifier.citedreferenceHam J., Babij C., Whitfield J., Pfarr C. M., Lallemand D., Yaniv M. & Rubin L. L. ( 1995 ) A c- jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron 14, 927 – 939.en_US
dc.identifier.citedreferenceIchijo H., Nishida E., Irie K., Dijke P., Saitoh M., Moriguchi T., Takagi   M., Matsumoto K., Miyazono K. & Gotoh Y. ( 1997 ) Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 275, 90 – 94.en_US
dc.identifier.citedreferenceKharbanda S., Pandey P., Schofield L., Israels S., Roncinske R., Yoshida K., Bharti A., Yuan Z.-M., Saxena S., Weichselbaum R., Nalin C. & Kufe D. ( 1997 ) Role for Bcl-x L as an inhibitor of cytosolic cytochrome  c accumulation in DNA damage-induced apoptosis. Proc. Natl Acad. Sci. USA 94, 6939 – 6942.en_US
dc.identifier.citedreferenceKim B., Cheng H.-L., Margolis B. & Feldman E. L. ( 1998a ) Insulin receptor substrate-2 and Shc play different roles in insulin-like growth factor-I signaling. J. Biol. Chem. 273, 34543 – 34550.en_US
dc.identifier.citedreferenceKim B. & Feldman E. L. ( 1998b ) Differential regulation of focal adhesion kinase and mitogen-activated protein kinase tyrosine phosphorylation during insulin-like growth factor-I-mediated cytoskeletal reorganization. J. Neurochem. 71, 1333 – 1336.en_US
dc.identifier.citedreferenceKluck R. M., Bossy-Wetzel E., Green D. R. & Newmeyer D. D. ( 1997 ) The release of cytochrome  c from mitochondria: a primary site for Bcl-2 regulation of apoptosis [see comments]. Science 275, 1132 – 1136.en_US
dc.identifier.citedreferenceKroemer G., Dallaporta B. & Resche-Rigon M. ( 1998 ) The mitochondrial death/life regulator in apoptosis and necrosis. Annu. Rev. Physiol. 60, 619 – 642.en_US
dc.identifier.citedreferenceKyriakis J. M., Banerjee P., Nikolakaki E., Dai T., Rubie E. A., Ahmad   M. F., Avruch J. & Woodgett J. R. ( 1994 ) The stress-activated protein kinase subfamily of c-June kinases. Nature 369, 156 – 160.en_US
dc.identifier.citedreferenceKyriakis J. M., Woodgett J. R. & Avruch J. ( 1995 ) The stress-activated protein kinases. Ann. NY Acad. Sci. 766, 303 – 319.en_US
dc.identifier.citedreferenceLee J. C., Laydon J. T., McDonnell P. C., Gallagher T. F., Kumar S., Green D., McNulty D., Blumenthal M. J., Heys J. R., Landvatter   S. W., Strickler J. E., McLaughlin M. M., Siemens I. R., Fisher S. M., Livi G. P., White J. R., Adams J. L. & Young P. R. ( 1994 ) A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372, 739 – 746.en_US
dc.identifier.citedreferenceLee L. F., Li G., Templeton D. J. & Ting J. P. ( 1998 ) Paclitaxel (Taxol)-induced gene expression and cell death are both mediated by the activation of c-June NH 2 -terminal kinase (JNK/SAPK). J.  Biol. Chem. 273, 28253 – 28260.en_US
dc.identifier.citedreferenceLeventhal P. S., Shelden E. A., Kim B. & Feldman E. L. ( 1997 ) Tyrosine phosphorylation of paxillin and focal adhesion kinase during insulin-like growth factor-I-stimulated lamellipodial advance. J. Biol. Chem. 272, 5214 – 5218.en_US
dc.identifier.citedreferenceLeventhal P. S., Russell J. W. & Feldman E. L. ( 1999 ) IGFs and the nervous system, in Contemporary Endocrinology: The IGF System ( Rosenfeld R. and Roberts C. T. Jr, eds), pp. 425 – 455. Humana Press, Totowa, NJ.en_US
dc.identifier.citedreferenceMatthews C. C. & Feldman E. L. ( 1996 ) Insulin-like growth factor I rescues SH-SY5Y human neuroblastoma cells from hyperosmotic induced programmed cell death. J. Cell. Physiol. 166, 323 – 331.en_US
dc.identifier.citedreferenceMatthews C. C., Odeh H. & Feldman E. L. ( 1997 ) Insulin-like growth factor-I is an osmoprotectant in human neuroblastoma cells. Neuroscience 79, 525 – 534.en_US
dc.identifier.citedreferenceMinden A., Lin A., McMahon M., Lange-Carter C., Derijard B., Davis   R. J., Johnson G. L. & Karin M. ( 1994 ) Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science 266, 1719 – 1723.en_US
dc.identifier.citedreferenceOkubo Y., Blakesley V. A., Stannard B., Gutkind S. & Le Roith D. ( 1998 ) Insulin-like growth factor-I inhibits the stress-activated protein kinase/c-June N-terminal kinase. J. Biol. Chem. 273, 25961 – 25966.en_US
dc.identifier.citedreferencePandey P., Avraham S., Place A., Kumar V., Majumder P. K., Cheng   K., Nakazawa A., Saxena S. & Kharbanda S. ( 1999 ) Bcl-xL blocks activation of related adhesion focal tyrosine kinase/proline-rich tyrosine kinase 2 and stress-activated protein kinase/c-June N-terminal protein kinase in the cellular response to methylmethane sulfonate. J. Biol. Chem. 274, 8618 – 8623.en_US
dc.identifier.citedreferencePark J., Kim I., Oh Y. J., Lee K., Han P. L. & Choi E. J. ( 1997 ) Activation of c-June N-terminal kinase antagonizes an anti-apoptotic action of Bcl-2. J. Biol. Chem. 272, 16725 – 16728.en_US
dc.identifier.citedreferencePark D. S., Stefanis L., Yan C. Y. I., Farinelli S. E. & Greene L. A. ( 1996 ) Ordering the cell death pathway. J. Biol. Chem. 271, 21898 – 21905.en_US
dc.identifier.citedreferenceParsadanian A. S., Cheng Y., Keller-Peck C. R., Holtzman D. M. & Snider W. D. ( 1998 ) Bcl-xL is an antiapoptotic regulator for postnatal CNS neurons. J. Neurosci. 18, 1009 – 1019.en_US
dc.identifier.citedreferencePotapova O., Haghighi A., Bost F., Liu C., Birrer M. J., Gjerset R. & Mercola D. ( 1997 ) The June kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin. J. Biol. Chem. 272, 14041 – 14044.en_US
dc.identifier.citedreferencePyne S., Chapman J., Steele L. & Pyne N. J. ( 1996 ) Sphigomyelin-derived lipids differently regulate the extracellular signal-regulated kinase 2 (ERK2) and c-jun N-terminal kinase (JNK) signal cascades in airway smooth muscle. Eur. J. Biochem. 237, 819 – 826.en_US
dc.identifier.citedreferenceRukenstein A., Rydel R. E. & Greene L. A. ( 1991 ) Multiple agents resue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms. J. Neurosci. 11, 2552 – 2563.en_US
dc.identifier.citedreferenceRussell J. W., Windebank A. J., Schenone A. & Feldman E. L. ( 1998 ) Insulin-like growth factor-I prevents apoptosis in neurons after nerve growth factor withdrawal. J. Neurobiol. 36, 455 – 467.en_US
dc.identifier.citedreferenceRussell J. W., Sullivan K. A., Windebank A. J., Herrmann D. N. & Feldman E. L. ( 1999 ) Neurons undergo apoptosis in animal and cell culture models of diabetes. Neurobiol. Dis. 6, 347 – 363.en_US
dc.identifier.citedreferenceSanchez-Perez I. & Perona R. ( 1999 ) Lack of c-June activity increases survival to cisplatin. FEBS Lett. 453, 151 – 158.en_US
dc.identifier.citedreferenceSchendel S. L., Montal M. & Reed J. C. ( 1998 ) Bcl-2 family proteins as ion-channels. Cell Death Differ. 5, 372 – 380.en_US
dc.identifier.citedreferenceSingleton J. R., Dixit V. M. & Feldman E. L. ( 1996a ) Type I insulin-like growth factor receptor activation regulates apoptotic proteins. J. Biol. Chem. 271, 31791 – 31794.en_US
dc.identifier.citedreferenceSingleton J. R., Randolph A. E. & Feldman E. L. ( 1996b ) Insulin-like growth factor I receptor prevents apotosis and enhances neuroblastoma tumorigenesis. Cancer Res. 56, 4522 – 4529.en_US
dc.identifier.citedreferenceSlee E. A., Harte M. T., Kluck R. M., Wolf B. B., Casiano C. A., Newmeyer D. D., Wang H. G., Reed J. C., Nickolson D. W., Alnemri E. S., Green D. R. & Martin S. J. ( 1999 ) Ordering the cytochrome  c -initiated caspase cascade: hierarchical activation of caspases-2,3,6,7,8, and 10 in a caspase-9 dependent manner. J.  Cell Biol. 144, 281 – 292.en_US
dc.identifier.citedreferenceSoilu-Hanninen M., Ekert P., Bucci T., Syroid D., Bartlett P. F. & Kilpatrick T. J. ( 1999 ) Nerve growth factor signaling through p75 induces apoptosis in Schwann cells via a Bcl-2-independent pathway. J. Neurosci. 19, 4828 – 4838.en_US
dc.identifier.citedreferenceSrivastava R. K., Sollott S. J., Khan L., Hansford R., Lakatta E. G. & Longo D. L. ( 1999 ) Bcl-2 and Bcl-X(L) block thapsigargin-induced nitric oxide generation, c June NH(2)-terminal kinase activity, and apoptosis. Mol. Cell Biol. 19, 5659 – 5674.en_US
dc.identifier.citedreferenceStewart H. J. S., Mirsky R. & Jessen K. R. ( 1996 ) The Schwann cell lineage: embryonic and early postnatal development, in Glial Cell Development ( Jessen K. R. and Richardson W. D., eds), pp. 1 – 30. BIOS Scientific Publishers Limited, Oxford.en_US
dc.identifier.citedreferenceSu B. & Karin M. ( 1996 ) Mitogen-activated protein kinase cascades and regulation of gene expression. Curr. Opin. Immunol. 8, 402 – 411.en_US
dc.identifier.citedreferenceSyroid D. E., Maycox P. R., Burrola P. G., Liu N. L., Wen D. Z., Lee   K. F., Lemke G. & Kilpatrick T. J. ( 1996 ) Cell death in the Schwann cell lineage and its regulation by neuregulin. Proc. Natl Acad. Sci. USA 93, 9229 – 9234.en_US
dc.identifier.citedreferenceSyroid D. E., Zorick T. S., Arbet-Engels C., Kilpatrick T. J., Eckhart W. & Lemke G. ( 1999 ) A role for insulin-like growth factor-I in the regulation of Schwann cell survival. J. Neurosci. 19, 2059 – 2068.en_US
dc.identifier.citedreferenceTassi E., Biesova Z., Di Fiore P. P., Gutkind J. S. & Wong W. T. ( 1999 ) Human JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factor. J. Biol. Chem. 274, 33287 – 33295.en_US
dc.identifier.citedreferenceUsdin T. B. & Fischbach G. D. ( 1986 ) Purification and characterization of a polypeptide from chick brain that promotes the accumulation of acetylcholine receptors in chick myotubes. J.  Cell Biol. 103, 493 – 507.en_US
dc.identifier.citedreferenceVander Heiden M. G., Chandel N. S., Williamson E. K., Schumacker   P. T. & Thompson C. B. ( 1997 ) Bcl-xl regulates the membrane potential and volume homeostasis of mitochondria. Cell 91, 627 – 637.en_US
dc.identifier.citedreferenceVander Heiden M. G., Chandel N. S., Schumacker P. T. & Thompson C. B. ( 1999 ) Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange. Mol. Cell 3, 159 – 167.en_US
dc.identifier.citedreferenceVerheij M., Bose R., Lin X. H., Yao B., Jarvis W. D., Grant S., Birrer   M. J., Szabo E., Zon L. I., Kyriakis J. M., Haimovitz-Friedman A., Fuks Z. & Kolesnick R. N. ( 1996 ) Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 380, 75 – 79.en_US
dc.identifier.citedreferenceWang T. H., Popp D. M., Wang H. S., Saitoh M., Mural J. G., Henley   D. C., Ichijo H. & Wimalasena J. ( 1999 ) Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-June N-terminal kinase (JNK)-dependent and -independent pathways in ovarian cancer cells. J. Biol. Chem. 274, 8208 – 8216.en_US
dc.identifier.citedreferenceWoodgett J. R., Avruch J. & Kyriakis J. M. ( 1995 ) Regulation of nuclear transcription factors by stress signals. Clin. Exp. Pharmacol. Physiol. 22, 281 – 283.en_US
dc.identifier.citedreferenceXia Z., Dickens M., Raingeaud J., Davis R. J. & Greenberg M. E. ( 1995 ) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326 – 1331.en_US
dc.identifier.citedreferenceXu L., Koumenis I. L., Tilly J. L. & Giffard R. G. ( 1999 ) Overexpression of bcl-xL protects astrocytes from glucose deprivation and is associated with higher glutathione, ferritin, and iron levels. Anesthesiology 91, 1036 – 1046.en_US
dc.identifier.citedreferenceZeigler M. E., Chi Y., Schmidt T. & Varani J. ( 1999 ) Role of ERK and JNK pathways in regulating cell motility and matrix metalloproteinase 9 production in growth factor-stimulated human epidermal keratinocytes. J. Cell. Physiol. 180, 271 – 284.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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