View Item 

Show simple item record

EFFECT OF METHIONINE AND METHIONINE SULPHOXIMINE ON RAT BRAIN S -ADENOSYL METHIONINE LEVELS

dc.contributor.authorSchatz, Robert A.en_US
dc.contributor.authorSellinger, Otto Z.en_US
dc.date.accessioned2010-04-01T14:53:47Z
dc.date.available2010-04-01T14:53:47Z
dc.date.issued1975-01en_US
dc.identifier.citationSchatz, R. A.; Sellinger, O. Z. (1975). "EFFECT OF METHIONINE AND METHIONINE SULPHOXIMINE ON RAT BRAIN S -ADENOSYL METHIONINE LEVELS." Journal of Neurochemistry 24(1): 63-66. <http://hdl.handle.net/2027.42/65351>en_US
dc.identifier.issn0022-3042en_US
dc.identifier.issn1471-4159en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/65351
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1110368&dopt=citationen_US
dc.description.abstractRat brain SAM levels were markedly increased after methionine administration, whereas the convulsant, L-methionine-dl-sulphoximine (MSO), produced a 35 per cent decrease in whole brain content of S -adenosyl-L-methionine (SAM). When methionine was given in combination with MSO, SAM levels were not decreased. Studies on the regional distribution of SAM revealed only a small variation between regions (from 24 nmol/g in midbrain to 49-5 nmol/g in striatum). SAM levels were reduced by about 50 per cent in the cerebellum, striatum, cortex and hippocampus 3 and 6 h after MSO. It is proposed that abberant cerebral methylation processes may be involved in the genesis of the MSO seizure.en_US
dc.format.extent281289 bytes
dc.format.extent3110 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.rights1975 International Society for Neurochemistryen_US
dc.titleEFFECT OF METHIONINE AND METHIONINE SULPHOXIMINE ON RAT BRAIN S -ADENOSYL METHIONINE LEVELSen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumLaboratory of Neurochemistry, Mental Health Research Institute, University of Michigan Medical Center, Ann Arbor, MI 48104, U. S. A.en_US
dc.identifier.pmid1110368en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/65351/1/j.1471-4159.1975.tb07628.x.pdf
dc.identifier.doi10.1111/j.1471-4159.1975.tb07628.xen_US
dc.identifier.sourceJournal of Neurochemistryen_US
dc.identifier.citedreferenceBaldessarin R. J. ( 1966 ) Biochem. Pharmac. 15, 741 – 748.en_US
dc.identifier.citedreferenceBaldessarini R. J. & Kopin I. J. ( 1966 ) J. Neurochem. 13, 769 – 777.en_US
dc.identifier.citedreferenceCohn C. K., Vesell E. S. & Axelro J. ( 1972 ) Biochem. Pharmac. 21, 803 – 809.en_US
dc.identifier.citedreferenceDe Roberti. E., Sellinger O. Z., Rodriguez De Lores Arnai. G., Alberic M. & Zieher L. M. ( 1967 ) J. Neurochem. 14, 81 – 89.en_US
dc.identifier.citedreferenceGhittoni N. E., Ohlsson W. G. & Sellinger O. Z. ( 1970 ) J. Neurochem. 17, 1057 – 1068.en_US
dc.identifier.citedreferenceGlowinsk J. & Iversen L. L. ( 1966 ) J. Neurochem. 13, 655 – 669.en_US
dc.identifier.citedreferenceLamar C. Jr. & Sellinger O. Z. ( 1965 ) Biochem. Pharmac. 14, 489 – 506.en_US
dc.identifier.citedreferenceLodi Z. & Kolouse J. ( 1958 ) Physiol Bohemoslov. 7, 292 – 298.en_US
dc.identifier.citedreferenceLombardini J. B., Coulter A. W. & Talala P. ( 1970 ) Molec. Pharmac. 6, 481 – 499.en_US
dc.identifier.citedreferenceLombardini J. B. & Talala P. ( 1971 ) Advances in Enzyme Regulation 9, 349 – 384.en_US
dc.identifier.citedreferenceMeins F. Jr. & Abrams M. L. ( 1972 ) Biochim. biophys. Acta 266, 307 – 311.en_US
dc.identifier.citedreferenceReine L., Misan F. & Weis P. ( 1950 ) Archs. Biochem. Biophys. 25, 447 – 454.en_US
dc.identifier.citedreferenceSalvator F., Util R., Zappi V. & Shapiro S. K. ( 1971 ) Analyt. Biochem. 41, 16 – 28.en_US
dc.identifier.citedreferenceSchat R., Diez-altares M. C. & Sellinger O. Z. ( 1973 ) Trans. Am. Soc. Neurochem. 4, 74.en_US
dc.identifier.citedreferenceSellinger O. Z., Azcurra J. M. & Ohlsson W. G. ( 1968 ) J. Pharmac. exp. Ther. 164, 212 – 222.en_US
dc.identifier.citedreferenceShapiro S. K. & Ehninger D. J. ( 1966 ) Analyt. Biochem. 15, 323 – 333.en_US
dc.identifier.citedreferenceWon F. F. ( 1971 ) J. Chromatogr. 59, 448 – 457.en_US
dc.identifier.citedreferenceWurtman R. J., Rose C. M., Matthyss S., Stephenso J. & Baldessarini R. J. ( 1970 ) Science, N. Y. 169, 395 – 397.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
j.1471-4159.1975.tb07628.x.pdf
Size:
274.6KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.