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Transient changes in nucleus accumbens amino acid concentrations correlate with individual responsivity to the predator fox odor 2,5-dihydro-2,4,5-trimethylthiazoline

dc.contributor.authorVenton, Barbara Jillen_US
dc.contributor.authorRobinson, Terry E.en_US
dc.contributor.authorKennedy, Robert T.en_US
dc.date.accessioned2010-04-01T14:54:55Z
dc.date.available2010-04-01T14:54:55Z
dc.date.issued2006-01en_US
dc.identifier.citationVenton, B. Jill; Robinson, Terry E.; Kennedy, Robert T. (2006). "Transient changes in nucleus accumbens amino acid concentrations correlate with individual responsivity to the predator fox odor 2,5-dihydro-2,4,5-trimethylthiazoline." Journal of Neurochemistry 96(1): 236-246. <http://hdl.handle.net/2027.42/65371>en_US
dc.identifier.issn0022-3042en_US
dc.identifier.issn1471-4159en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/65371
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16300631&dopt=citationen_US
dc.description.abstractPredator odors elicit fear and defensive behavioral responses in rats, but a wide range of individual responsivity exists. The aim of this study was to examine whether individual differences in behavioral responsivity correlate with differences in amino acid neurotransmission to a predator fox odor, 2,5-dihydro-2,4,5-trimethylthiazoline (TMT). We investigated the time course of behaviorally evoked amino acid neurotransmitter changes in the nucleus accumbens using on-line microdialysis coupled to capillary electrophoresis with 14-s temporal resolution. One subset of animals (high responders) showed a large, biphasic increase in amino acids, such as glutamate and GABA, which lasted about 3 min. These neurochemical changes were highly correlated with increases in locomotion and burrowing, but lagged behind the behavioral changes by 2 min. A second subset of rats (low responders) showed neither behavioral activation nor changes in amino acid neurotransmission. As a positive control, rats were subjected to tail pinch, which evoked transient changes in amino acids in all animals. Cocaine (2 mg/kg, i.v.) increased locomotion but not amino acid levels. This work demonstrates that rapid and transient increases in amino acid neurotransmitters correlate with behavioral reactivity to salient stimuli.en_US
dc.format.extent413620 bytes
dc.format.extent3110 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Science Ltden_US
dc.rights2005 The Authors Journal Compilation 2005 International Society for Neurochemistryen_US
dc.subject.otherCapillary Electrophoresisen_US
dc.subject.otherCocaineen_US
dc.subject.otherFox Odoren_US
dc.subject.otherGlutamateen_US
dc.subject.otherTail Pinchen_US
dc.subject.otherTaurineen_US
dc.titleTransient changes in nucleus accumbens amino acid concentrations correlate with individual responsivity to the predator fox odor 2,5-dihydro-2,4,5-trimethylthiazolineen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationum† Pharmacology, University of Michigan, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationother* Chemistryen_US
dc.contributor.affiliationother† Psychologyen_US
dc.identifier.pmid16300631en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/65371/1/j.1471-4159.2005.03549.x.pdf
dc.identifier.doi10.1111/j.1471-4159.2005.03549.xen_US
dc.identifier.sourceJournal of Neurochemistryen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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