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Variation in 5' Promoter Region of the APOE gene Contributes to Predicting Ischemic Heart Disease (IHD) in the Population at Large: the Copenhagen City Heart Study

dc.contributor.authorStengård, J. H.en_US
dc.contributor.authorFrikke-Schmidt, Ruthen_US
dc.contributor.authorTybjæ;rg-Hansen, A.en_US
dc.contributor.authorNordestgaard, B. G.en_US
dc.contributor.authorSing, Charles F.en_US
dc.date.accessioned2010-04-01T14:56:09Z
dc.date.available2010-04-01T14:56:09Z
dc.date.issued2007-11en_US
dc.identifier.citationStengÅrd, J. H.; Frikke-Schmidt, R.; TybjÆ;rg-Hansen, A.; Nordestgaard, B.G.; Sing, C.F. (2007). "Variation in 5' Promoter Region of the APOE gene Contributes to Predicting Ischemic Heart Disease (IHD) in the Population at Large: the Copenhagen City Heart Study." Annals of Human Genetics 71(6): 762-771. <http://hdl.handle.net/2027.42/65393>en_US
dc.identifier.issn0003-4800en_US
dc.identifier.issn1469-1809en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/65393
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17535270&dopt=citationen_US
dc.description.abstractThe objective of this study was to evaluate whether an increased hazard of developing ischemic heart disease (IHD) is associated with any of the three genotypes A 560 T 832 /A 560 T 832 , A 560 T 832 /A 560 G 832 and A 560 T 832 /T 560 T 832, defined by variations in two non-coding SNPs in the 5′ promoter region of the apolipoprotein E ( APOE) gene. These genotypes were selected because they distinguished between high and low levels of HDL-C, TG and/or T-C in our earlier study of multiple samples defined by gender and population. We found a significant increase (p<0.05) in the hazard of IHD in females with the A 560 T 832 /T 560 T 832 genotype that remained significant after fitting the effects of dyslipidemia, other established risk factors, and the structural isoform variations of the ApoE molecule. We discuss why this statistically significant genetic predictor may not be an appropriate screening test for IHD in the Danish population at large.en_US
dc.format.extent186394 bytes
dc.format.extent3110 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Publishing Ltden_US
dc.rights2007 The Authors Journal compilation © 2007 University College Londonen_US
dc.subject.otherAPOE Geneen_US
dc.subject.otherRegulatory Variationen_US
dc.subject.otherPrediction of IHDen_US
dc.titleVariation in 5' Promoter Region of the APOE gene Contributes to Predicting Ischemic Heart Disease (IHD) in the Population at Large: the Copenhagen City Heart Studyen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationotherDepartment of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166 FIN-00300, Helsinki, Finlanden_US
dc.contributor.affiliationotherDepartment of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark DK-2100en_US
dc.contributor.affiliationotherDepartment of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark DK-2730en_US
dc.identifier.pmid17535270en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/65393/1/j.1469-1809.2007.00370.x.pdf
dc.identifier.doi10.1111/j.1469-1809.2007.00370.xen_US
dc.identifier.sourceAnnals of Human Geneticsen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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