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Mechanisms and functional significance of aberrant seizure-induced hippocampal neurogenesis

dc.contributor.authorParent, Jack M.en_US
dc.contributor.authorMurphy, Geoffrey G.en_US
dc.date.accessioned2010-04-01T14:57:03Z
dc.date.available2010-04-01T14:57:03Z
dc.date.issued2008-06en_US
dc.identifier.citationParent, Jack M.; Murphy, Geoffrey G. (2008). "Mechanisms and functional significance of aberrant seizure-induced hippocampal neurogenesis." Epilepsia 49(s5 Persistent Hippocampal Neurogenesis ): 19-25. <http://hdl.handle.net/2027.42/65409>en_US
dc.identifier.issn0013-9580en_US
dc.identifier.issn1528-1167en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/65409
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18522597&dopt=citationen_US
dc.description.abstractStudies of experimental mesial temporal lobe epilepsy (mTLE) indicate that prolonged seizures in the adult not only damage the hippocampal formation but also dramatically stimulate neurogenesis. Endogenous neural progenitor cells (NPCs) located in the adult rodent dentate gyrus and striatal subventricular zone are stimulated by experimental status epilepticus (SE) to generate increased numbers of dentate granule cells (DGCs) and olfactory interneurons, respectively ( Bengzon et al., 1997 ; Parent et al., 1997, 2002 ; Scott et al., 1998 ). In this review, we discuss current knowledge regarding the consequences of seizure activity on NPC proliferation, focusing on the hippocampus, and on the migration and integration of adult-born hippocampal neurons. We also describe the effects of seizure-induced neurogenesis on hippocampal network function and the potential relevance of aberrant neurogenesis to human mTLE.en_US
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dc.publisherBlackwell Publishing Incen_US
dc.rights© 2008 by the International League Against Epilepsyen_US
dc.subject.otherAdulten_US
dc.subject.otherDentate Gyrusen_US
dc.subject.otherEpileptic Networken_US
dc.subject.otherHilar Ectopic Granule Cellsen_US
dc.subject.otherNeural Progenitor Cellsen_US
dc.subject.otherMesial Temporal Lobe Epilepsyen_US
dc.subject.otherStatus Epilepticusen_US
dc.titleMechanisms and functional significance of aberrant seizure-induced hippocampal neurogenesisen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMedicine (General)en_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationum§ Molecular and Behavioral Neuroscience Institute, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A.en_US
dc.contributor.affiliationother* Department of Neurologyen_US
dc.contributor.affiliationother† Neuroscience Graduate Programen_US
dc.contributor.affiliationother† Department of Molecular and Integrative Physiologyen_US
dc.identifier.pmid18522597en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/65409/1/j.1528-1167.2008.01634.x.pdf
dc.identifier.doi10.1111/j.1528-1167.2008.01634.xen_US
dc.identifier.sourceEpilepsiaen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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