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Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury
dc.contributor.authorThyfault, John P.en_US
dc.contributor.authorRector, R. Scotten_US
dc.contributor.authorUptergrove, Grace M.en_US
dc.contributor.authorBorengasser, Sarah J.en_US
dc.contributor.authorMorris, E. Matthewen_US
dc.contributor.authorWei, Yongzhongen_US
dc.contributor.authorLaye, Matt J.en_US
dc.contributor.authorBurant, Charles F.en_US
dc.contributor.authorQi, Nathan R.en_US
dc.contributor.authorRidenhour, Suzanne E.en_US
dc.contributor.authorKoch, Lauren G.en_US
dc.contributor.authorBritton, Steve L.en_US
dc.contributor.authorIbdah, Jamal A.en_US
dc.date.accessioned2010-04-01T14:57:10Z
dc.date.available2010-04-01T14:57:10Z
dc.date.issued2009-04-15en_US
dc.identifier.citationThyfault, John P.; Rector, R. Scott; Uptergrove, Grace M.; Borengasser, Sarah J.; Morris, E. Matthew; Wei, Yongzhong; Laye, Matt J.; Burant, Charles F.; Qi, Nathan R.; Ridenhour, Suzanne E.; Koch, Lauren G.; Britton, Steve L.; Ibdah, Jamal A. (2009). "Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury." The Journal of Physiology 587(8): 1805-1816. <http://hdl.handle.net/2027.42/65411>en_US
dc.identifier.issn0022-3751en_US
dc.identifier.issn1469-7793en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/65411
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=19237421&dopt=citationen_US
dc.format.extent548151 bytes
dc.format.extent3110 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.rightsJournal compilation © 2009 The Physiological Societyen_US
dc.titleRats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injuryen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPhysiologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumInternal Medicine, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationotherHarry S. Truman Memorial VA Hospital, Research Service, Columbia, MO 65201, USAen_US
dc.contributor.affiliationotherDepartments of Internal Medicine—Division of Gastroenterology and Hepatologyen_US
dc.contributor.affiliationotherNutritional Sciencesen_US
dc.contributor.affiliationotherMedical Pharmacology and Physiology, University of Missouri, Columbia, MO 65211, USAen_US
dc.contributor.affiliationotherPhysical Medicine and Rehabilitationen_US
dc.identifier.pmid19237421en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/65411/1/jphysiol.2009.169060.pdf
dc.identifier.doi10.1113/jphysiol.2009.169060en_US
dc.identifier.sourceThe Journal of Physiologyen_US
dc.identifier.citedreferenceBellentani S, Saccoccio G, Masutti F, Croce LS, Brandi G, Sasso F, Cristanini G & Tiribelli C ( 2000 ). Prevalence of and risk factors for hepatic steatosis in Northern Italy. Ann Intern Med 132, 112 – 117.en_US
dc.identifier.citedreferenceBernal-Mizrachi C & Semenkovich CF ( 2006 ). Fast predators or fast food, the fit still survive. Nat Med 12, 46 – 47 ; discussion 47.en_US
dc.identifier.citedreferenceBlair SN, Kohl HW 3rd, Paffenbarger RS Jr, Clark DG, Cooper KH & Gibbons LW ( 1989 ). Physical fitness and all-cause mortality. A prospective study of healthy men and women. JAMA 262, 2395 – 2401.en_US
dc.identifier.citedreferenceBouchard C, Lesage R, Lortie G, Simoneau JA, Hamel P, Boulay MR, Perusse L, Theriault G & Leblanc C ( 1986 ). Aerobic performance in brothers, dizygotic and monozygotic twins. Med Sci Sports Exerc 18, 639 – 646.en_US
dc.identifier.citedreferenceBouchard C & Rankinen T ( 2001 ). Individual differences in response to regular physical activity. Med Sci Sports Exerc 33, S446 – 451 ; discussion S452–453.en_US
dc.identifier.citedreferenceBrady LJ, Brady PS, Romsos DR & Hoppel CL ( 1985 ). Elevated hepatic mitochondrial and peroxisomal oxidative capacities in fed and starved adult obese (ob/ob) mice. Biochem J 231, 439 – 444.en_US
dc.identifier.citedreferenceBrowning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, Grundy SM & Hobbs HH ( 2004 ). Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 40, 1387 – 1395.en_US
dc.identifier.citedreferenceChen J, Petersen DR, Schenker S & Henderson GI ( 2000 ). Formation of malondialdehyde adducts in livers of rats exposed to ethanol: role in ethanol-mediated inhibition of cytochrome c oxidase. Alcoholism Clin Exp Res 24, 544 – 552.en_US
dc.identifier.citedreferenceChurch TS, Kuk JL, Ross R, Priest EL, Biltoft E & Blair SN ( 2006 ). Association of cardiorespiratory fitness, body mass index, and waist circumference to nonalcoholic fatty liver disease. Gastroenterology 130, 2023 – 2030.en_US
dc.identifier.citedreferenceDemeilliers C, Maisonneuve C, Grodet A, Mansouri A, Nguyen R, Tinel M, Letteron P, Degott C, Feldmann G, Pessayre D & Fromenty B ( 2002 ). Impaired adaptive resynthesis and prolonged depletion of hepatic mitochondrial DNA after repeated alcohol binges in mice. Gastroenterology 123, 1278 – 1290.en_US
dc.identifier.citedreferenceHawley JA & Spargo FJ ( 2006 ). It's all in the genes, so pick your parents wisely. J Appl Physiol 100, 1751 – 1752.en_US
dc.identifier.citedreferenceHorton JD, Goldstein JL & Brown MS ( 2002 ). SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109, 1125 – 1131.en_US
dc.identifier.citedreferenceHoydal MA, Wisloff U, Kemi OJ, Britton SL, Koch LG, Smith GL & Ellingsen O ( 2007 ). Nitric oxide synthase type-1 modulates cardiomyocyte contractility and calcium handling: association with low intrinsic aerobic capacity. Eur J Cardiovasc Prev Rehabil 14, 319 – 325.en_US
dc.identifier.citedreferenceIbdah JA, Perlegas P, Zhao Y, Angdisen J, Borgerink H, Shadoan MK, Wagner JD, Matern D, Rinaldo P & Cline JM ( 2005 ). Mice heterozygous for a defect in mitochondrial trifunctional protein develop hepatic steatosis and insulin resistance. Gastroenterology 128, 1381 – 1390.en_US
dc.identifier.citedreferenceKohrt WM, Malley MT, Coggan AR, Spina RJ, Ogawa T, Ehsani AA, Bourey RE, Martin WH 3rd & Holloszy JO ( 1991 ). Effects of gender, age, and fitness level on response of V O2max to training in 60–71 yr olds. J Appl Physiol 71, 2004 – 2011.en_US
dc.identifier.citedreferenceKoves TR, Noland RC, Bates AL, Henes ST, Muoio DM & Cortright RN ( 2005 ). Subsarcolemmal and intermyofibrillar mitochondria play distinct roles in regulating skeletal muscle fatty acid metabolism. Am J Physiol Cell Physiol 288, C1074 – 1082.en_US
dc.identifier.citedreferenceLaye MJ, Rector RS, Borengasser SJ, Naples SP, Uptergrove GM, Ibdah JA, Booth FW & Thyfault JP ( 2008 ). Cessation of daily wheel running differentially alters fat oxidation capacity in liver, muscle, and adipose tissue. J Appl Physiol 106, 161 – 168.en_US
dc.identifier.citedreferenceLaye MJ, Thyfault JP, Stump CS & Booth FW ( 2006 ). Inactivity induces increases in abdominal fat. J Appl Physiol 102, 1341 – 1347.en_US
dc.identifier.citedreferenceMcGarry JD, Mannaerts GP & Foster DW ( 1977 ). A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis. J Clin Invest 60, 265 – 270.en_US
dc.identifier.citedreferenceMcMillan KP, Kuk JL, Church TS, Blair SN & Ross R ( 2007 ). Independent associations between liver fat, visceral adipose tissue, and metabolic risk factors in men. Appl Physiol Nutr Metab 32, 265 – 272.en_US
dc.identifier.citedreferenceMemon RA, Tecott LH, Nonogaki K, Beigneux A, Moser AH, Grunfeld C & Feingold KR ( 2000 ). Up-regulation of peroxisome proliferator-activated receptors (PPAR-Α) and PPAR-Γ messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-Γ-responsive adipose tissue-specific genes in the liver of obese diabetic mice. Endocrinology 141, 4021 – 4031.en_US
dc.identifier.citedreferenceMiele L, Grieco A, Armuzzi A, Candelli M, Forgione A, Gasbarrini A & Gasbarrini G ( 2003 ). Hepatic mitochondrial Β-oxidation in patients with nonalcoholic steatohepatitis assessed by 13 C-octanoate breath test. Am J Gastroenterol 98, 2335 – 2336.en_US
dc.identifier.citedreferenceMootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstrale M, Laurila E, Houstis N, Daly MJ, Patterson N, Mesirov JP, Golub TR, Tamayo P, Spiegelman B, Lander ES, Hirschhorn JN, Altshuler D & Groop LC ( 2003 ). PGC-1Α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 34, 267 – 273.en_US
dc.identifier.citedreferenceMyers J, Prakash M, Froelicher V, Do D, Partington S & Atwood JE ( 2002 ). Exercise capacity and mortality among men referred for exercise testing. N Engl J Med 346, 793 – 801.en_US
dc.identifier.citedreferenceNguyen-Duy TB, Nichaman MZ, Church TS, Blair SN & Ross R ( 2003 ). Visceral fat and liver fat are independent predictors of metabolic risk factors in men. Am J Physiol Endocrinol Metab 284, E1065 – 1071.en_US
dc.identifier.citedreferenceNoland RC, Thyfault JP, Henes ST, Whitfield BR, Woodlief TL, Evans JR, Lust JA, Britton SL, Koch LG, Dudek RW, Dohm GL, Cortright RN & Lust RM ( 2007 a ). Artificial selection for high capacity endurance running is protective against high fat diet-induced insulin resistance. Am J Physiol Endocrinol Metab 293, E31 – 41.en_US
dc.identifier.citedreferenceNoland RC, Woodlief TL, Whitfield BR, Manning SM, Evans JR, Dudek RW, Lust RM & Cortright RN ( 2007 b ). Peroxisomal-mitochondrial oxidation in a rodent model of obesity-associated insulin resistance. Am J Physiol Endocrinol Metab 293, E986 – E1001.en_US
dc.identifier.citedreferencePerez-Carreras M, Del Hoyo P, Martin MA, Rubio JC, Martin A, Castellano G, Colina F, Arenas J & Solis-Herruzo JA ( 2003 ). Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis. Hepatology 38, 999 – 1007.en_US
dc.identifier.citedreferencePetersen KF, Dufour S, Befroy D, Garcia R & Shulman GI ( 2004 ). Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med 350, 664 – 671.en_US
dc.identifier.citedreferenceRector RS, Thyfault JP, Morris RT, Laye MJ, Borengasser SJ, Booth FW & Ibdah JA ( 2008 ). Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats. Am J Physiol Gastrointest Liver Physiol 294, G619 – 626.en_US
dc.identifier.citedreferenceReddy JK & Hashimoto T ( 2001 ). Peroxisomal Β-oxidation and peroxisome proliferator-activated receptor Α: an adaptive metabolic system. Annu Rev Nutr 21, 193 – 230.en_US
dc.identifier.citedreferenceReddy JK & Rao MS ( 2006 ). Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation. Am J Physiol Gastrointest Liver Physiol 290, G852 – 858.en_US
dc.identifier.citedreferenceSanyal AJ, Campbell-Sargent C, Mirshahi F, Rizzo WB, Contos MJ, Sterling RK, Luketic VA, Shiffman ML & Clore JN ( 2001 ). Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 120, 1183 – 1192.en_US
dc.identifier.citedreferenceSchindhelm RK, Diamant M, Dekker JM, Tushuizen ME, Teerlink T & Heine RJ ( 2006 ). Alanine aminotransferase as a marker of non-alcoholic fatty liver disease in relation to type 2 diabetes mellitus and cardiovascular disease. Diabetes Metab Res Rev 22, 437 – 443.en_US
dc.identifier.citedreferenceSchoonjans K, Staels B & Auwerx J ( 1996 ). The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation. Biochim Biophys Acta 1302, 93 – 109.en_US
dc.identifier.citedreferenceSchoonjans K, Watanabe M, Suzuki H, Mahfoudi A, Krey G, Wahli W, Grimaldi P, Staels B, Yamamoto T & Auwerx J ( 1995 ). Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter. J Biol Chem 270, 19269 – 19276.en_US
dc.identifier.citedreferenceShimano H, Horton JD, Hammer RE, Shimomura I, Brown MS & Goldstein JL ( 1996 ). Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J Clin Invest 98, 1575 – 1584.en_US
dc.identifier.citedreferenceShimomura I, Bashmakov Y & Horton JD ( 1999 ). Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. J Biol Chem 274, 30028 – 30032.en_US
dc.identifier.citedreferenceSmall GM, Burdett K & Connock MJ ( 1985 ). A sensitive spectrophotometric assay for peroxisomal acyl-CoA oxidase. Biochem J 227, 205 – 210.en_US
dc.identifier.citedreferenceWei Y, Clark SE, Morris EM, Thyfault JP, Uptergrove GM, Whaley-Connell AT, Ferrario CM, Sowers JR & Ibdah JA ( 2008 ). Angiotensin II-induced non-alcoholic fatty liver disease is mediated by oxidative stress in transgenic TG(mRen2)27(Ren2) rats. J Hepatol 49, 417 – 428.en_US
dc.identifier.citedreferenceWisloff U, Najjar SM, Ellingsen O, Haram PM, Swoap S, Al-Share Q, Fernstrom M, Rezaei K, Lee SJ, Koch LG & Britton SL ( 2005 ). Cardiovascular risk factors emerge after artificial selection for low aerobic capacity. Science 307, 418 – 420.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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