Runx1 expression defines a subpopulation of displaced amacrine cells in the developing mouse retina
dc.contributor.author | Stewart, Lee | en_US |
dc.contributor.author | Potok, Mary Anne | en_US |
dc.contributor.author | Camper, Sally A. | en_US |
dc.contributor.author | Stifani, Stefano | en_US |
dc.date.accessioned | 2010-04-01T14:59:01Z | |
dc.date.available | 2010-04-01T14:59:01Z | |
dc.date.issued | 2005-09 | en_US |
dc.identifier.citation | Stewart, Lee; Potok, Mary Anne; Camper, Sally A.; Stifani, Stefano (2005). " Runx1 expression defines a subpopulation of displaced amacrine cells in the developing mouse retina." Journal of Neurochemistry 94(6): 1739-1745. <http://hdl.handle.net/2027.42/65442> | en_US |
dc.identifier.issn | 0022-3042 | en_US |
dc.identifier.issn | 1471-4159 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/65442 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16026391&dopt=citation | en_US |
dc.description.abstract | AML1 Runx1 (Runx1) is a mammalian transcription factor that plays critical roles in regulating the differentiation of a number of different cell types. In the present study, we have utilized mice expressing -galactosidase ( -gal) under the control of the Runx1 promoter to characterize the spatiotemporal expression pattern of Runx1 during retinogenesis. Expression of -gal was first detected at embryonic day 13.5 in post-mitotic cells located in the inner retina and overlapped with expression of the early amacrine and ganglion cell marker protein Islet1. During subsequent developmental stages, the number of -gal-positive cells increased in a central-to-peripheral gradient until late embryogenesis but then decreased in the early post-natal retina. -gal-positive cells were located primarily in the ganglion cell layer by late embryonic early post-natal stages and were identified as a subpopulation of displaced amacrine cells by the continued expression of Islet1, as well as Pax6, and the coexpression of the amacrine cell subtype-specific markers choline acetyltransferase, calretinin and the 65-kDa isoform of glutamic acid decarboxylase. These findings identify Runx1 as a novel marker for a restricted amacrine cell subtype and suggest a role for this gene in regulating the post-mitotic development of these cells. | en_US |
dc.format.extent | 489770 bytes | |
dc.format.extent | 3110 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Science Ltd | en_US |
dc.rights | 2005 International Society for Neurochemistry | en_US |
dc.subject.other | Amacrine Cells | en_US |
dc.subject.other | Choline Acetyltransferase | en_US |
dc.subject.other | Ganglion Cell Layer | en_US |
dc.subject.other | 65-kDa Isoform of Glutamic Acid Decarboxylase | en_US |
dc.subject.other | Retina | en_US |
dc.subject.other | Runx1 | en_US |
dc.title | Runx1 expression defines a subpopulation of displaced amacrine cells in the developing mouse retina | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Center for Neuronal Survival, Montreal Neurological Institute, Montreal, Quebec, Canada | en_US |
dc.identifier.pmid | 16026391 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/65442/1/j.1471-4159.2005.03336.x.pdf | |
dc.identifier.doi | 10.1111/j.1471-4159.2005.03336.x | en_US |
dc.identifier.source | Journal of Neurochemistry | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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