Choroid Plexus Potassium Cotransport: Modulation by Osmotic Stress and External Potassium
dc.contributor.author | Xiang, Jianming | en_US |
dc.date.accessioned | 2010-04-01T15:03:48Z | |
dc.date.available | 2010-04-01T15:03:48Z | |
dc.date.issued | 1995-06 | en_US |
dc.identifier.citation | Xiang, Jianming (1995). "Choroid Plexus Potassium Cotransport: Modulation by Osmotic Stress and External Potassium." Journal of Neurochemistry 64(6): 2747-2754. <http://hdl.handle.net/2027.42/65526> | en_US |
dc.identifier.issn | 0022-3042 | en_US |
dc.identifier.issn | 1471-4159 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/65526 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7760055&dopt=citation | en_US |
dc.description.abstract | The choroid plexuses are involved in CSF secretion and CSF K homeostasis. This study examines the potential role of K cotransport in these two processes using isolated rat lateral ventricle choroid plexuses. Bumetanide-sensitive 86 Rb influx and efflux were measured to assess the response of K cotransport to changes in media osmolality and K concentration. Alterations in osmolality had no effect on K uptake (in the presence or absence of bumetanide). However, the efflux rate constant for K was 0.29 ± 0.02, 0.44 ± 0.04, and 0.84 ± 0.06 min −1 in 240, 300, and 424 mOsm/kg solutions, respectively ( p < 0.001). This increase in efflux with osmolality, an opposite effect to that found in many cells, was solely due to enhanced K cotransport. The increased cotransport may be involved in limiting brain shrinkage during hyperosmotic stress if the cotransporter is present on the apical membrane. The rate of bumetanide-sensitive efflux was unaffected by changes in external [K]. However, the rate of K uptake (measured on return to normal [K] media) was reduced gradually by exposure to low [K]. It was 21 ± 1, 19 ± 3, 13 ± 2, and 6 ± 1 nmol/mg/min after 0, 10, 30, and 60-min exposure to 1 m M K. Sixty minutes of exposure to 1 m M [K] abolished the bumetanide-sensitive K uptake present in plexuses exposed continually to normal media. This modulation of K cotransport by external [K] may be important in CSF K homeostasis by limiting K loss from the CSF if CSF [K] is low. | en_US |
dc.format.extent | 831979 bytes | |
dc.format.extent | 3110 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Science Ltd | en_US |
dc.rights | Blackwell Science Inc | en_US |
dc.subject.other | CSF | en_US |
dc.subject.other | Choroid Plexus | en_US |
dc.subject.other | Potassium Cotransport | en_US |
dc.subject.other | Potassium Homeostasis | en_US |
dc.subject.other | 86 Rb | en_US |
dc.subject.other | Volume Regulation | en_US |
dc.title | Choroid Plexus Potassium Cotransport: Modulation by Osmotic Stress and External Potassium | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Surgery (Neurosurgery), University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.identifier.pmid | 7760055 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/65526/1/j.1471-4159.1995.64062747.x.pdf | |
dc.identifier.doi | 10.1046/j.1471-4159.1995.64062747.x | en_US |
dc.identifier.source | Journal of Neurochemistry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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