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Mechanisms of Unexplained Anemia in the Nursing Home

dc.contributor.authorArtz, Andrew S.en_US
dc.contributor.authorFergusson, Deanen_US
dc.contributor.authorDrinka, Paul J.en_US
dc.contributor.authorGerald, Melvinen_US
dc.contributor.authorBidenbender, Rexen_US
dc.contributor.authorLechich, Anthonyen_US
dc.contributor.authorSilverstone, Felixen_US
dc.contributor.authorMccamish, Mark A.en_US
dc.contributor.authorDai, Jinluen_US
dc.contributor.authorKeller, Evan T.en_US
dc.contributor.authorErshler, William B.en_US
dc.date.accessioned2010-04-01T15:16:25Z
dc.date.available2010-04-01T15:16:25Z
dc.date.issued2004-03en_US
dc.identifier.citationArtz, Andrew S.; Fergusson, Dean; Drinka, Paul J.; Gerald, Melvin; Bidenbender, Rex; Lechich, Anthony; Silverstone, Felix; Mccamish, Mark A.; Dai, Jinlu; Keller, Evan; Ershler, William B. (2004). "Mechanisms of Unexplained Anemia in the Nursing Home." Journal of the American Geriatrics Society 52(3): 423-427. <http://hdl.handle.net/2027.42/65745>en_US
dc.identifier.issn0002-8614en_US
dc.identifier.issn1532-5415en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/65745
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=14962159&dopt=citationen_US
dc.description.abstractTo characterize anemia in elderly nursing home residents. Design : Prospective multiinstitutional cohort study. Setting : Five nursing homes. Participants : From retrospective analysis, residents found to be anemic using chart review were prospectively randomized. Of the 81 residents enrolled, 60 were anemic. Measurements : Chart review for medical history and factors related to treatment or history of anemia, extensive laboratory evaluation for causes of anemia, and classification of anemia by two hematologists. Results : Among the 60 anemic residents, the causes of anemia were idiopathic (n=27), iron-deficiency (n=14), anemia associated with chronic disease (n=8), anemia of renal insufficiency (n=6), and other (n=5). The eryrthropoietin (EPO) response to anemia was lower in residents with idiopathic anemia (IA) than in those with iron-deficiency anemia, and this correlated with renal function as estimated using calculated creatinine clearance. In this elderly population, advancing age was not correlated with lower EPO response. Conclusion : IA is common in nursing home residents. A lower EPO response contributes to the high prevalence of anemia in this setting and may be due, in part, to occult renal dysfunction.en_US
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dc.format.extent3110 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Science Incen_US
dc.rights© 2004 by the American Geriatrics Societyen_US
dc.subject.otherElderlyen_US
dc.subject.otherAnemiaen_US
dc.subject.otherErythropoietinen_US
dc.subject.otherRenal Insufficiencyen_US
dc.subject.otherFrailen_US
dc.titleMechanisms of Unexplained Anemia in the Nursing Homeen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelGeriatricsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumProgram of Immunology and Department of Pathology, University of Michigan, Ann Arbor, Michigan.en_US
dc.contributor.affiliationotherInstitute for Advanced Studies in Aging and Geriatric Medicine, Washington, DC ;en_US
dc.contributor.affiliationotherNational Geriatrics Research Consortium, Washington, DC ;en_US
dc.contributor.affiliationotherUniversity of Chicago Medical Center, Chicago, Illinois ;en_US
dc.contributor.affiliationotherOttawa Hospital Research Institute, Ottawa, Canada ;en_US
dc.contributor.affiliationotherWisconsin Veterans Home, King, Wisconsin ;en_US
dc.contributor.affiliationotherWashington Nursing Facility, Washington, DC ;en_US
dc.contributor.affiliationotherEastern Virginia Medical School, Norfolk, Virginia ;en_US
dc.contributor.affiliationotherCenter Terence Cardinal Cooke Health Care Center, New York, New York ;en_US
dc.contributor.affiliationotherParker Jewish Institute for Health Care and Rehabilitation, New Hyde Park, New York ;en_US
dc.contributor.affiliationotherAmgen, Inc., Thousand Oaks, California ; anden_US
dc.identifier.pmid14962159en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/65745/1/j.1532-5415.2004.52116.x.pdf
dc.identifier.doi10.1111/j.1532-5415.2004.52116.xen_US
dc.identifier.sourceJournal of the American Geriatrics Societyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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