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Variance and Sample Size Calculations in Quality-of-Life-Adjusted Survival Analysis (Q-TWiST)

dc.contributor.authorMurray, Susanen_US
dc.contributor.authorCole, Bernarden_US
dc.date.accessioned2010-04-01T15:18:20Z
dc.date.available2010-04-01T15:18:20Z
dc.date.issued2000-03en_US
dc.identifier.citationMurray, Susan; Cole, Bernard (2000). "Variance and Sample Size Calculations in Quality-of-Life-Adjusted Survival Analysis (Q-TWiST)." Biometrics 56(1): 173-182. <http://hdl.handle.net/2027.42/65778>en_US
dc.identifier.issn0006-341Xen_US
dc.identifier.issn1541-0420en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/65778
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10783793&dopt=citationen_US
dc.description.abstractThe Quality-Adjusted Time Without Symptoms or Toxicity (Q-TWiST) statistic previously introduced by Glasziou, Simes and Gelber (1990, Statistics in Medicine 9 , 1259–1276) combines toxicity, disease-free survival, and overall survival information in assessing the impact of treatments on the lives of patients. This methodology has received positive reviews from clinicians as intuitive and useful, but to date, the variance of this statistic has remained unspecified. We review aspects of the Q-TWiST method for analyzing clinical trial data, extend the method to accommodate multiple treatment arms, and provide closed-form asymptotic variance formulas. We also provide a framework for designing Q-TWiST clinical trials with sample sizes determined using the derived asymptotic variance formulas. Trials currently collecting quality of life data did not have the benefit of these sample size calculation techniques in designing their studies.en_US
dc.format.extent983866 bytes
dc.format.extent3110 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.rightsThe International Biometric Society, 2000en_US
dc.subject.otherDependent Kaplan-Meier Estimatesen_US
dc.subject.otherQuality of Lifeen_US
dc.subject.otherSample Sizeen_US
dc.subject.otherSurvivalen_US
dc.titleVariance and Sample Size Calculations in Quality-of-Life-Adjusted Survival Analysis (Q-TWiST)en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMathematicsen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, U.S.A. email: skmurray@umich.eduen_US
dc.contributor.affiliationotherDepartment of Community and Family Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, U.S.A.en_US
dc.identifier.pmid10783793en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/65778/1/j.0006-341X.2000.00173.x.pdf
dc.identifier.doi10.1111/j.0006-341X.2000.00173.xen_US
dc.identifier.sourceBiometricsen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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